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Volume 14 Issue 3, March 2013

Research Highlight

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In Brief

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Research Highlight

  • Identifies sites of Fzo1 ubiquitylation and DUBs that counteract this to influence mitochondrial fusion.

    • Katharine H. Wrighton
    Research Highlight
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In Brief

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Research Highlight

  • Spp1 recruits potential double-strand break sites to the repair machinery during meiosis.

    • Alison Schuldt
    Research Highlight
  • Histone acetylation regulates BRCA1 and 53BP1 localization to DNA double-strand breaks.

    • Andrea Du Toit
    Research Highlight
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Progress

  • Amino acids are one of the key environmental stimuli signalling to mTOR. Although exactly how they are sensed and how they activate mTOR has remained elusive, a model has emerged that implicates signalling by RAG GTPases, Ragulator and v-ATPase at the lysosome and leucyl t-RNA synthetase in the cytoplasm.

    • Jenna L. Jewell
    • Ryan C. Russell
    • Kun-Liang Guan
    Progress
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Review Article

  • The growth and maturation of mammalian oocytes rely on the communication with ovarian somatic cells as well as on dynamic cytoskeleton-based events. Increasing evidence suggests that self-organizing microtubules and motor proteins direct meiotic spindle assembly and actin filaments control spindle positioning and oocyte polarity, while meiotic chromatin provides key instructive signals.

    • Rong Li
    • David F. Albertini
    Review Article
  • The prevalence and physiological importance of alternative splicing in multicellular eukaryotes has led to increased interest in its control. Much has been learnt about how transcription and chromatin structure influence splicing events, as well as the effects of signalling pathways, and this understanding may hold promise for the development of gene therapies.

    • Alberto R. Kornblihtt
    • Ignacio E. Schor
    • Manuel J. Muñoz
    Review Article
  • Structural data has provided insight into the molecular mechanisms that modulate fibroblast growth factor (FGF) signalling to generate distinct biological outputs in development, tissue homeostasis and metabolism. Mechanisms include alternative splicing of ligand and receptor, homodimerization and site-specific proteolytic cleavage of ligand, and interaction of ligand and receptor with heparan sulphate and Klotho co-receptors.

    • Regina Goetz
    • Moosa Mohammadi
    Review Article
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Opinion

  • Both microRNAs (miRNAs) and other small non-coding RNAs (ncRNAs) are induced by DNA breaks and have been linked to the DNA damage response. This interplay between ncRNAs and repair factors may help to ensure efficient DNA repair and maintenance of genome stability.

    • Dipanjan Chowdhury
    • Young Eun Choi
    • Marie Eve Brault
    Opinion
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