Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The TFIIH complex has an integral role in both nucleotide excision repair and transcription. Studies of TFIIH are therefore defining a new model for crosstalk between the factors that orchestrate DNA repair and transcription, as well as the concept of 'transcription diseases'.
Traditionally, ribosomes have been viewed as invariable complexes with ubiquitous function in mRNA translation. However, ribosome specialization, resulting from the differential expression and cell type-specific modification of its components, seems to greatly contribute to the diversity of biological processes.
During the first division of meiosis, homologous chromosomes are pulled to opposite poles and segregated to daughter cells. This form of chromosome segregation, which differs from what occurs in mitosis, is facilitated by meiosis-specific changes to chromosomes as well as by kinetochore geometry and tension exerted by microtubules.
The glucose transporter GLUT4 ensures controlled glucose uptake into fat and muscle cells. By targeting several steps in the membrane trafficking of GLUT4, insulin signalling allows tight regulation of glucose homeostasis and prevents the development of insulin resistance.
Metabolic signalling pathways and telomere shortening are both thought to, independently, have crucial roles in driving the ageing process. But links between these two processes suggest that they may converge on mitochondria to compromise energy maintenance, thereby driving ageing.
