Volume 13 Issue 6, June 2012

Volume 13 Issue 6

Research Highlights

Reviews

  • Review Article |

    The TFIIH complex has an integral role in both nucleotide excision repair and transcription. Studies of TFIIH are therefore defining a new model for crosstalk between the factors that orchestrate DNA repair and transcription, as well as the concept of 'transcription diseases'.

    • Emmanuel Compe
    •  & Jean-Marc Egly
  • Review Article |

    Traditionally, ribosomes have been viewed as invariable complexes with ubiquitous function in mRNA translation. However, ribosome specialization, resulting from the differential expression and cell type-specific modification of its components, seems to greatly contribute to the diversity of biological processes.

    • Shifeng Xue
    •  & Maria Barna
  • Review Article |

    During the first division of meiosis, homologous chromosomes are pulled to opposite poles and segregated to daughter cells. This form of chromosome segregation, which differs from what occurs in mitosis, is facilitated by meiosis-specific changes to chromosomes as well as by kinetochore geometry and tension exerted by microtubules.

    • Yoshinori Watanabe
  • Review Article |

    The glucose transporter GLUT4 ensures controlled glucose uptake into fat and muscle cells. By targeting several steps in the membrane trafficking of GLUT4, insulin signalling allows tight regulation of glucose homeostasis and prevents the development of insulin resistance.

    • Dara Leto
    •  & Alan R. Saltiel

Perspectives

    Opinion

  • Opinion |

    Metabolic signalling pathways and telomere shortening are both thought to, independently, have crucial roles in driving the ageing process. But links between these two processes suggest that they may converge on mitochondria to compromise energy maintenance, thereby driving ageing.

    • Ergün Sahin
    •  & Ronald A. DePinho

Erratum