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Phosphatase and tensin homologue (PTEN) governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular architecture. Unravelling its enzymatic activities, its signalling partners, and the molecular mechanisms involved in the multiple levels of PTEN regulation will aid the design of novel PTEN-based therapeutic interventions in cancer.
Histone demethylases are important for both chromatin structure and transcription. The insights being gained into their regulation and target specificity have important implications for both normal development and disease.
O-GlcNAcylation is a post-translational modification that seems to regulate the function of numerous target proteins in a nutrient-sensitive manner. Recent evidence suggests an important role forO-GlcNAcylation in epigenetic regulation.
Endocytic recycling, for some time considered to occur by default, is now emerging as an active sorting process. These studies are increasing our understanding of the physiological events that require recycling.
Increasing evidence suggests that cell-to-cell communication in mammals can occur through the exchange of genetic information, mainly in the form of microRNAs (miRNAs). This exchange can be mediated by extracellular vesicles such as exosomes through intimate membrane contacts between donor and acceptor cells, or a combination of both.
