Volume 12 Issue 8, August 2011

From The Editors

Research Highlights


  • Review Article |

    The regulation of mitotic exit requires the rapid reversal of mitotic phosphorylation on a broad range of substrates. This requires not only inactivation of mitotic kinases but also activation of protein phosphatases, which work in regulatory networks to ensure that an interphase cell is correctly established.

    • Claudia Wurzenberger
    •  & Daniel W. Gerlich
  • Review Article |

    In eukaryotes, RNA polymerases I, II and III synthesize RNAs, which are essential for life. Remarkably, plants have evolved two additional multisubunit RNA polymerases, RNA polymerases IV and V, to orchestrate non-coding RNA-mediated gene silencing processes. Their subunit compositions reveal that they evolved as specialized forms of RNA polymerase II.

    • Jeremy R. Haag
    •  & Craig S. Pikaard
  • Review Article |

    RHO-specific guanine nucleotide dissociation inhibitors (RHOGDIs) had long been considered to be passive inhibitors of RHO GTPases, 'locking' them in an inactive state. However, recent findings suggest that they have integral roles in regulating RHO GTPases, controlling aspects such as stability, expression, activity and membrane localization.

    • Rafael Garcia-Mata
    • , Etienne Boulter
    •  & Keith Burridge
  • Review Article |

    RNA helicases of the DEAD box family are highly conserved enzymes with many roles in gene expression. Structural and mechanistic studies are uncovering the basis of their actions and have revealed roles not only in RNA unwinding but also in the remodelling of RNA–protein complexes and in the clamping of RNA to allow nucleation of larger complexes.

    • Patrick Linder
    •  & Eckhard Jankowsky
  • Review Article |

    Clathrin-mediated endocytosis is a modular process that involves core and accessory adaptor proteins that package cargoes into vesicles, ultimately leading to their uptake. It is essential for many physiological processes in higher eukaryotes, including signal termination and exocytosis, so its components are rarely associated with disease.

    • Harvey T. McMahon
    •  & Emmanuel Boucrot