Volume 12 Issue 6, June 2011

Volume 12 Issue 6

From The Editors

Research Highlights


  • Review Article |

    Muscle differentiation during development is regulated by transcription factor networks and microRNAs, and postnatal changes in muscle phenotype and mass are controlled by anabolic and catabolic signalling. Recent studies have elucidated the hierarchies of these signalling networks and have identified proteins that act both during development and in postnatal adaptation.

    • Thomas Braun
    •  & Mathias Gautel
  • Review Article |

    The ADP-ribosylation factor (ARF) and ARF-like (ARL) family of G proteins, which are known to regulate membrane traffic and organelle structure, are emerging as regulators of diverse processes, including lipid and cytoskeletal transport. Although traditionally viewed as part of a linear signalling pathway, ARFs and their regulators must now be considered to exist within functional networks, in which both the 'inactive' ARF and the regulators themselves can mediate distinct effects.

    • Julie G. Donaldson
    •  & Catherine L. Jackson



  • Opinion |

    The production of mature and export-competent messenger ribonucleoproteins (mRNPs) is a multistep process that is regulated in a spatial and temporal manner. Recent studies suggest that post-translational modifications play a part in coordinating the co-transcriptional assembly, remodelling and export of mRNP complexes through nuclear pores.

    • Evelina Tutucci
    •  & Françoise Stutz
  • Opinion |

    The improper distribution of chromosomes during mitosis can contribute to malignant transformation. Higher eukaryotes have developed strategies for eliminating mitosis-incompetent cells, one of which is mitotic catastrophe. From a functional perspective, mitotic catastrophe can be defined as an oncosuppressive mechanism that precedes (and is distinct from) apoptosis, necrosis or senescence.

    • Ilio Vitale
    • , Lorenzo Galluzzi
    • , Maria Castedo
    •  & Guido Kroemer
  • Opinion |

    Alan Turing showed that spatial patterns can be generated when two morphogens diffuse and react. Although he realized the importance of mechanics, it has only recently become clear that mechanical processes (forces and flows generated by motors) can also contribute to patterning when coupled to chemical reactions.

    • Jonathon Howard
    • , Stephan W. Grill
    •  & Justin S. Bois