Volume 11 Issue 4, April 2010

Volume 11 Issue 4

'Wrap artist' by Vicky Summersby, inspired by the Review on p264, and the work of the artists Christo and Jeanne-Claude.

From The Editors

Research Highlights

Reviews

  • Review Article |

    The actin cytoskeleton has key roles in many dynamic cellular processes, such as cell movement, cell division and membrane dynamics. The discovery of mammalian proteins that regulate actin nucleation and dynamics has expanded our views on how the actin cytoskeleton influences cellular functions.

    • Kenneth G. Campellone
    •  & Matthew D. Welch
  • Review Article |

    Signalling pathways are ideal candidates for microRNA-mediated regulation owing to the sharp dose-sensitive nature of their effects. Emerging evidence suggests that microRNAs affect the responsiveness of cells to various growth factors, serving as nodes of signalling networks that ensure homeostasis and regulate disease.

    • Masafumi Inui
    • , Graziano Martello
    •  & Stefano Piccolo
  • Review Article |

    Histone core particles are spools for wrapping DNA, whereas histone variants have evolved diverse additional roles in chromosome metabolism. Some variants mediate universal functions, such as chromosome segregation and DNA repair, and others specialize in organism-specific tasks.

    • Paul B. Talbert
    •  & Steven Henikoff
  • Review Article |

    The ERMs (ezrin, moesin and radixin) are key organizers of membrane domains because they can interact with transmembrane proteins and the cytoskeleton. Recent studies have provided insights into the regulation of ERMs and their in vivo roles in development, immune responses and disease.

    • Richard G. Fehon
    • , Andrea I. McClatchey
    •  & Anthony Bretscher
  • Review Article |

    Integrin activation comprises initial and intermediate signalling events and, finally, the interaction of integrins with cytoplasmic regulators such as talins and kindlins, which changes an integrin's affinity for its ligands. Targeting of these final, integrin-specific, activation events enables integrin-focused therapeutic strategies.

    • Sanford J. Shattil
    • , Chungho Kim
    •  & Mark H. Ginsberg

Perspectives

    Opinion

  • Opinion |

    Neurodegenerative diseases are associated with the accumulation of intracellular or extracellular protein aggregates that form because of protein misfolding. These aggregates are capable of crossing cellular membranes and can thereby directly contribute to the propagation of neurodegenerative disease pathogenesis, which might spread in a 'prion-like' manner.

    • Patrik Brundin
    • , Ronald Melki
    •  & Ron Kopito