July 2019

Cellular organization and biology of the respiratory system

A visual guide to the cell types that make the respiratory tract and its architecture, and to the lung cell culture models that can be used to study the pathophysiology of the respiratory system.

March 2017

Bone marrow niches and HSC fates

Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate all mature blood cells.

July 2015

Stem cell states: naive to primed pluripotency

Pluripotency refers to the ability of cells to differentiate into cell types of all three embryonic germ layers.

October 2011

From teratomas to embryonic stem cells: discovering pluripotency

This year marks the thirtieth anniversary since mouse embryonic stem (ES) cells were first isolated from blastocysts.

June 2011

The identity and properties of mesenchymal stem cells

Mesenchymal stem cells (MSCs) are multipotent progenitor cells that were originally identified in the bone marrow stroma, where they regulate key stages of haematopoiesis.

April 2011

Autophagy: molecular mechanisms and disease outcomes

During autophagy, double-membrane structures called autophagosomes engulf cytosol or organelles and deliver them to lysosomes (in mammalian cells) or the vacuole (in yeast) to be degraded and recycled.

October 2010

Fluorescent proteins illuminate cell biology

The discovery that green fluorescent protein (GFP) from the jellyfish Aequorea victoria could be used to label proteins in cells led to a revolution in our ability to track proteins in live cells and whole organisms.

May 2010

Ubiquitin signalling by ubiquitin-binding domains

Ubiquitylation is a highly regulated process that tags proteins to specify distinct functional outcomes.

March 2010

Cellular regulation by deubiquitinating enzymes

Ubiquitination is a reversible post-translational modification with key roles in protein stability, as well as in various signal transduction cascades, membrane trafficking and mitosis.

December 2009

The rise of p53

In 1979 the discovery of p53 was reported. The gene encoding p53 (TP53) was initially believed to be an oncogene but 10 years later it was correctly characterized as a tumour suppressor, which led to a steep rise in p53 research.

February 2009

Production and actions of small RNAs

Recent progress in cloning, deep sequencing and bioinformatics have revealed an astounding landscape of small RNAs in eukaryotic cells.

September 2008

Pluripotent cell isolation for regenerative medicine

Pluripotent cells offer great promise for the future of regenerative medicine and tissue engineering. This Poster by Christopher Lengner and Rudolf Jaenisch compares and contrasts the properties of pluripotent embryonic stem cells with those of laboratory-generated pluripotent cells.

February 2008

Targeting lipid signalling in disease

Lipids are important mediators in cancer and inflammation, and in cardiovascular, neurodegenerative and metabolic diseases.

December 2007

Readout of chromatin marks by histone–binding modules

Histones can be covalently modified by the addition of various chemical appendages, and distinct histone marks are associated with most DNA transactions (transcription, repair, and so on) and have been implicated as carriers of epigenetic identity.

December 2006

Molecular mechanisms of stem-cell identity and fate

Stem cells have been identified and characterized in several mammalian tissues.

July 2006

Reading protein and phospholipid modifications with interaction domains

The protein complement that underlies the behaviour of any cell type is the result of selective gene expression and alternative RNA splicing.

August 2005

Ubiquitin and ubiquitin-like proteins

At the end of last year, the Nobel Prize in Chemistry 2004 was awarded in Stockholm, Sweden, to Aaron Ciechanover, Avram Hershko and Irwin Rose for their role in the discovery of a system for regulated protein degradation — the ubiquitin–proteasome system1.

November 2004

Apoptosis pathways and drug targets

Defects in the expression or function of proteins with either pro-apoptotic (indicated in red) or anti-apoptotic (green) consequences have a causative or contributing role in the pathogenesis or progression of several diseases.

September 2002

Signalling from the membrane to the nucleus

How do signals received at the cell membrane reach the nucleus?