News & Comment

The suppression of homologous recombination in G1 depends on BRCA1–PALB2–BRCA2 complex formation at sites of damage. In mitosis, DNA repair factors prevent the formation of DNA damage by facilitating mitotic replication.

Centrosomes can nucleate not only microtubules but also actin filaments, in a process dependent on the actin-related protein 2/3 complex and WASH.

Rong Li tells us about the discovery of the seven-subunit actin nucleator Arp2/3 complex.

Cytoplasmic, but not nuclear, aggregates of β-sheet proteins mediate toxic effects through impaired nucleo-cytoplasmic transport of mRNA and protein.

The ubiquitin ligase COP1 promotes insulin secretion in mice by inducing the degradation of transcription factors ETV1, ETV4 and ETV5.

The primase–polymerase PrimPol is required for bypassing G-quadruplexes in vertebrate cells by repriming replication downstream of the structures.

Cep135, Ana1 (Cep295) and Asterless (Cep152) are sequentially recruited to daughter centrioles to enable their maturation into duplication-competent mother centrioles.

M. Bishr Omary reminds us of the three articles that first uncovered a causative link between mutations in intermediate filaments (specifically, keratin 14) and human diseases.

Two studies provide novel insights into how the Dpp morphogen regulates fly wing growth.

Analyses ofDrosophila melanogasterpolytene chromosomes elucidate the interconnections between gene expression, genome organization into topologically associated domains (TADs) and the structures of euchromatin and heterochromatin.

Autophagy-induced degradation of the nuclear lamina protects cells from tumorigenesis

The Hippo signalling pathway regulates spindle orientation and asymmetric cell division

A novel protocol for protein interactome analysis in three dimensions identifies the crucial role of highly abundant, weak interactions.