News & Comment

To activate noncanonical LC3B lipidation and NLRP3 inflammasome formation, stimulator of interferon genes (STING) forms a proton channel in Golgi membranes.

Anne West recounts the study that showed postnatal accumulation of non-CpG DNA methylation in neurons coinciding with postnatal synapse maturation, suggesting that it contributes to brain function.

In the amphibian axolotl, the kinase mTOR is hyper-sensitive and activates a protein synthesis response that is crucial for wound healing and tissue regeneration.

Cutler and Vijg remind us of the publication that laid the foundation for genetic mutation theories of ageing.

In this Tools of the Trade article, Joleen Cheah (from the Ting lab) discusses the development of TransitID, which allows researchers to capture protein trafficking pathways in vivo without a priori knowledge of specific proteins of interest.

Cremer et al. show that the ubiquitin ligase RNF26 and vimentin-based intermediate filaments cooperate to control perinuclear ER membrane organization and thus facilitate recovery from ER stress.

Recent studies show that antigenic peptides are derived from the translation of precursor mRNAs. Robin Fåhraeus argues that it is therefore time to re-evaluate nuclear translation and its interesting implications.

In this Tools of the Trade article, Roffay and Mercier (from the Roux lab) describe the development of fluorescent Flipper probes that allow measurement of membrane mechanics in vivo.

Cycles of stretch and compression, such as during cell migration through tissues, lead to stabilization of microtubules owing to redistribution of the plus-end-binding protein CLASP2 along microtubule lengths.

Transcription factors bind RNA through an Arg-rich motif; these interactions potentially promote transcription and development, and their dissociation can contribute to disease.

Shi et al. show the role of myosin VI in the protection of stalled replication forks during replication stress.

Diana Pinheiro recounts two seminal papers describing how cell surface tension dictates how cells sort into different tissues during development.

During cellular stresses, the mRNA internal 7-methylguanosine (m⁷G) modification is bound by QKI-7, which regulates the stability and/or translation of the mRNAs by sequestering them in stress granules.

In this Tools of the Trade article, William Leineweber (from the Fraley lab) describes the set-up of an integrated biophysical imaging platform that allows researchers to assess the interactions between cells and the surrounding extracellular matrix.

The tight junction protein TJP1 is essential for controlling BMP signalling during patterning of human gastrulation models.

In this Tools of the Trade article, Edoardo José Longarini and Helen Dauben (from the Matić lab) describe the development and applications of mono-ADP-ribosylation antibodies and peptides.

Elfick and Wells-Holland promote a concerted effort to quantitatively characterize transfection methodologies.

Rogers et al. provide evidence that hypoxia is beneficial in mammalian ageing, extending the lifespan of prematurely ageing mice.

Subunits of the SWI/SNF chromatin remodelling complexes ‘bookmark’ cell-type specifying genes during mitosis to allow their timely reactivation upon mitosis exit.

In this Tools of the Trade article, Nouf Laqtom (at the Abu-Remaileh lab) describes the LysoIP system used to tag and isolate lysosomes for multi-omic approaches and to determine their composition under physiological and pathological states.