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  • In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis in mice (surgical connection between circulatory systems for an extended period), followed by detachment, can shed light on potential mechanisms that reverse mammalian ageing.

    • Bohan Zhang
    Tools of the Trade
  • Phosphorylation of the mitochondrial DNA (mtDNA) maintenance factor TFAM during spermatogenesis prevents its import into mitochondria, resulting in elimination of paternal mtDNA and leading to maternal inheritance.

    • Eytan Zlotorynski
    Research Highlight
  • Ernst and Renne highlight two papers, one that discovered and another that structurally defined the ER–mitochondria encounter structure (ERMES) that facilitates the exchange of lipids between the ER and mitochondria.

    • Mike F. Renne
    • Robert Ernst
    Journal Club
  • Congratulations to John Jumper and Demis Hassabis for winning the 2023 Albert Lasker Basic Medical Research Award.

    • Paulina Strzyz
    Research Highlight
  • In this Tools of the Trade article, Sarah Paramore (from the Devenport and Nelson labs) discusses the use of mouse strains carrying genomic alterations in PCP genes and how they can increase our understanding of mammalian planar cell polarity.

    • Sarah V. Paramore
    Tools of the Trade
  • The first study to show, in C. elegans, that sensory neurons have a role in lifespan regulation.

    • Patricija van Oosten-Hawle
    Journal Club
  • Antennapedia proteins were among the first proteins found to be exchanged intercellularly. This discovery by Alain Prochiantz and colleagues has inspired researchers of various backgrounds.

    • Jin Woo Kim
    Journal Club
  • Bulut-Karslıoğlu remembers the publication of two seminal papers that described bivalent chromatin and how this discovery continues to affect research to this day.

    • Aydan Bulut-Karslıoğlu
    Journal Club
  • To activate noncanonical LC3B lipidation and NLRP3 inflammasome formation, stimulator of interferon genes (STING) forms a proton channel in Golgi membranes.

    • Lisa Heinke
    Research Highlight
  • Anne West recounts the study that showed postnatal accumulation of non-CpG DNA methylation in neurons coinciding with postnatal synapse maturation, suggesting that it contributes to brain function.

    • Anne E. West
    Journal Club
  • In the amphibian axolotl, the kinase mTOR is hyper-sensitive and activates a protein synthesis response that is crucial for wound healing and tissue regeneration.

    • Eytan Zlotorynski
    Research Highlight
  • Cutler and Vijg remind us of the publication that laid the foundation for genetic mutation theories of ageing.

    • Ronald Cutler
    • Jan Vijg
    Journal Club
  • In this Tools of the Trade article, Joleen Cheah (from the Ting lab) discusses the development of TransitID, which allows researchers to capture protein trafficking pathways in vivo without a priori knowledge of specific proteins of interest.

    • Joleen S. Cheah
    Tools of the Trade
  • Cremer et al. show that the ubiquitin ligase RNF26 and vimentin-based intermediate filaments cooperate to control perinuclear ER membrane organization and thus facilitate recovery from ER stress.

    • Paulina Strzyz
    Research Highlight