News & Comment

  • Editorial |

    We reflect on the position of Nature Reviews Molecular Cell Biology, 20 years from its launch.

  • Research Highlight |

    The role of chromosome clustering as a driver of nucleo-cytoplasmic compartmentalization after mitosis.

    • Paulina Strzyz
  • Journal Club |

    A 2017 paper showed that phase separation and formation of elastin in the extracellular matrix does not require protein secondary structures, but cross-linked disordered chains.

    • Nicolas Lux Fawzi
  • Journal Club |

    Gavin Kelsey discusses the first reports of genomic imprinting in mammals and how they raised the profile of epigenetics in the study of mammalian development.

    • Gavin Kelsey
  • Journal Club |

    Twenty years ago it was reported that epithelial–mesenchymal transition (EMT), a key developmental process, occurs in cancer; many studies have since, and still are, studying EMT heterogeneity and its functional implications.

    • M. Angela Nieto
  • Journal Club |

    Although the organization of cell membranes into lipid rafts has become a key concept in cell biology, how partitioning of membrane components into subdomains is achieved remains an important question.

    • Anne K. Kenworthy
  • Comment |

    Michael Levin and colleagues discuss how computer-designed organisms ― biobots and xenobots ― are driving a new research field with applications in biomedicine and engineering, and associated ethical and philosophical questions.

    • M. Levin
    • , J. Bongard
    •  & J. E. Lunshof
  • Journal Club |

    Roland Wenger highlights discovery of HIFs and recent insights into their differential physiological roles.

    • Roland H. Wenger
  • Research Highlight |

    A new study demonstrates that glypicans shield the palmitoleate on WNTs to enable their distribution in tissues.

    • Paulina Strzyz
  • Journal Club |

    Ana García-Sáez highlights the continued interest in BCL-2 proteins and their mechanisms.

    • Ana J. García-Sáez
  • Comment |

    Circadian clocks control our immune system, infections and pharmacokinetics. Ray and Reddy argue that better understanding the effects of circadian biology on SARS-CoV-2 infection would improve COVID-19 management.

    • Sandipan Ray
    •  & Akhilesh B. Reddy
  • Research Highlight |

    DPPA2 and DPPA4 maintain promoter bivalency and low levels of DNA methylation at certain lineage-specific genes.

    • Eytan Zlotorynski
  • Research Highlight |

    Vietri et al. show that failure to repair micronuclear membranes is caused by unrestrained activity of ESCRT-III.

    • Paulina Strzyz
  • Research Highlight |

    Increased expression of the circular RNA generated by the sulfateless gene (circSfl), and of the protein it encodes, can extend the lifespan of flies.

    • Kim Baumann
  • Research Highlight |

    Young and colleagues show that anti-cancer compounds can undergo partitioning into biomolecular condensates, affecting their activity.

    • Paulina Strzyz
  • Research Highlight |

    A non-catalytic function of PRC1 is required for chromatin interactions that can facilitate developmental gene activation.

    • Eytan Zlotorynski
  • Research Highlight |

    Premalignant skin stem cells become dependent on extracellular serine for proliferation, and this metabolic reprogramming inhibits tumour-suppressing cell differentiation.

    • Kim Baumann
  • Comment |

    Hans Clevers discusses the value of organoids as an experimental platform for understanding the biology of novel viruses.

    • Hans Clevers
  • Research Highlight |

    Bass and colleagues uncover a role for NAD+ in preventing age-related decline in circadian function in mice.

    • Paulina Strzyz
  • Research Highlight |

    A group of endogenous 22-nucleotide siRNAs, which is produced by Dicer-like 2 proteins, represses translation and contributes to plant adaptation to environmental stress.

    • Kim Baumann
  • Journal Club |

    Ilya Levental outlines maturation of the concept of lipid rafts as an organizational principle of biomembranes.

    • Ilya Levental
  • Research Highlight |

    Mitochondrial fission at plasma membrane wounds induces local signalling via mitochondria-derived reactive oxygen species for membrane repair.

    • Paulina Strzyz
  • Research Highlight |

    The histone acetylation oncoprotein BRD4-NUT helps establish a nuclear subcompartment that supports high levels of gene expression.

    • Eytan Zlotorynski
  • Research Highlight |

    A new study in Molecular Cell shows that human mitochondrial DNA is enriched for the DNA modification N6-methyldeoxyadenosine, which can repress mitochondrial gene expression and regulate the transcriptional response to mitochondrial stress.

    • Joseph Willson
  • Research Highlight |

    In their study in Cell Liang et al. identify 200 regulators of ER-phagy and specifically dissect the role of mitochondrial oxidative metabolism and protein UFMylation in promoting ER-phagy.

    • Paulina Strzyz
  • Research Highlight |

    Tau post-translational modifications and their crosstalk contribute to the formation of disease-specific intracellular tau aggregates.

    • Kim Baumann
  • Research Highlight |

    Defective mitochondria in senescent cells activate a signalling pathway that promotes the senescence-associated secretory phenotype and inflammation.

    • Eytan Zlotorynski
  • Research Highlight |

    A new study in Science shows that AMPK is an inhibitor of caspase 6-driven hepatic cell death in non-alcoholic steatohepatitis.

    • Paulina Strzyz
  • Journal Club |

    In this Journal Club, Audrey Williams and Sally Horne-Badovinac highlight the importance of studying the basal cell surface and its dynamics to understand epithelial cell behaviours and tissue rearrangements.

    • Audrey M. Williams
    •  & Sally Horne-Badovinac
  • Research Highlight |

    In cells exposed to stiff extracellular matrix, sequestration of the ubiquitin ligase TRIM21 by actin stress fibres can prevent the ubiquitination and breakdown of the glycolytic enzyme PFK, directly linking mechanical sensing to metabolic regulation.

    • Joseph Willson
  • Research Highlight |

    DIX domains ― found in the plant SOSEKI proteins ― have a conserved role in enabling concentration-dependent protein polymerization and the assembly of cell polarity complexes.

    • Kim Baumann
  • Journal Club |

    Lluís Ribas de Pouplana outlines the unanswered questions of mitochondrial transcription.

    • Lluís Ribas de Pouplana
  • Research Highlight |

    Extopic expression of the XIST RNA at one chromosome 21 in iPSCs derived from individuals with Down syndrome leads to transcriptional silencing of chromosome 21 and improves iPSC differentiation into neurons.

    • Minju Ha