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Sally Lowell discusses the concept of ‘community effect’ when cells commit to a certain differentiation path, which was proposed by John Gurdon in 1988 and recently suggested to enable cancer cells to gain control.
Twenty years ago it was reported that epithelial–mesenchymal transition (EMT), a key developmental process, occurs in cancer; many studies have since, and still are, studying EMT heterogeneity and its functional implications.
Although the organization of cell membranes into lipid rafts has become a key concept in cell biology, how partitioning of membrane components into subdomains is achieved remains an important question.
Michael Levin and colleagues discuss how computer-designed organisms ― biobots and xenobots ― are driving a new research field with applications in biomedicine and engineering, and associated ethical and philosophical questions.
Circadian clocks control our immune system, infections and pharmacokinetics. Ray and Reddy argue that better understanding the effects of circadian biology on SARS-CoV-2 infection would improve COVID-19 management.
A new study in Molecular Cell shows that human mitochondrial DNA is enriched for the DNA modification N6-methyldeoxyadenosine, which can repress mitochondrial gene expression and regulate the transcriptional response to mitochondrial stress.
In this Journal Club, Audrey Williams and Sally Horne-Badovinac highlight the importance of studying the basal cell surface and its dynamics to understand epithelial cell behaviours and tissue rearrangements.
In cells exposed to stiff extracellular matrix, sequestration of the ubiquitin ligase TRIM21 by actin stress fibres can prevent the ubiquitination and breakdown of the glycolytic enzyme PFK, directly linking mechanical sensing to metabolic regulation.
Extopic expression of the XIST RNA at one chromosome 21 in iPSCs derived from individuals with Down syndrome leads to transcriptional silencing of chromosome 21 and improves iPSC differentiation into neurons.