News & Comment

  • Research Highlight |

    The discovery of the CRISPR–Cas9 system by Emmanuelle Charpentier and Jennifer Doudna awarded a 2020 Nobel Prize in Chemistry.

    • Paulina Strzyz
  • Research Highlight |

    A signalling pathway comprising TMO5–LHW and cytokinin controls plant adaptation to low-phosphate levels in the soil by increasing root hair density.

    • Eytan Zlotorynski
  • Research Highlight |

    Wozniak and colleagues reveal that cleavage of the lysosomal protein RILP following activation of the inflammasome enhances exosome release and regulates the trafficking of miRNAs into exosomes by FMR1.

    • Joseph Willson
  • Research Highlight |

    The switch from glycolytic metabolism to OXPHOS functions as a driver of cell immortalization during tumorigenesis in the fly brain.

    • Paulina Strzyz
  • Editorial |

    We reflect on the position of Nature Reviews Molecular Cell Biology, 20 years from its launch.

  • Research Highlight |

    The role of chromosome clustering as a driver of nucleo-cytoplasmic compartmentalization after mitosis.

    • Paulina Strzyz
  • Journal Club |

    A 2017 paper showed that phase separation and formation of elastin in the extracellular matrix does not require protein secondary structures, but cross-linked disordered chains.

    • Nicolas Lux Fawzi
  • Journal Club |

    Gavin Kelsey discusses the first reports of genomic imprinting in mammals and how they raised the profile of epigenetics in the study of mammalian development.

    • Gavin Kelsey
  • Journal Club |

    Twenty years ago it was reported that epithelial–mesenchymal transition (EMT), a key developmental process, occurs in cancer; many studies have since, and still are, studying EMT heterogeneity and its functional implications.

    • M. Angela Nieto
  • Journal Club |

    Although the organization of cell membranes into lipid rafts has become a key concept in cell biology, how partitioning of membrane components into subdomains is achieved remains an important question.

    • Anne K. Kenworthy
  • Comment |

    Michael Levin and colleagues discuss how computer-designed organisms ― biobots and xenobots ― are driving a new research field with applications in biomedicine and engineering, and associated ethical and philosophical questions.

    • M. Levin
    • , J. Bongard
    •  & J. E. Lunshof
  • Journal Club |

    Roland Wenger highlights discovery of HIFs and recent insights into their differential physiological roles.

    • Roland H. Wenger
  • Research Highlight |

    A new study demonstrates that glypicans shield the palmitoleate on WNTs to enable their distribution in tissues.

    • Paulina Strzyz
  • Journal Club |

    Ana García-Sáez highlights the continued interest in BCL-2 proteins and their mechanisms.

    • Ana J. García-Sáez
  • Comment |

    Circadian clocks control our immune system, infections and pharmacokinetics. Ray and Reddy argue that better understanding the effects of circadian biology on SARS-CoV-2 infection would improve COVID-19 management.

    • Sandipan Ray
    •  & Akhilesh B. Reddy
  • Research Highlight |

    DPPA2 and DPPA4 maintain promoter bivalency and low levels of DNA methylation at certain lineage-specific genes.

    • Eytan Zlotorynski
  • Research Highlight |

    Vietri et al. show that failure to repair micronuclear membranes is caused by unrestrained activity of ESCRT-III.

    • Paulina Strzyz
  • Research Highlight |

    Increased expression of the circular RNA generated by the sulfateless gene (circSfl), and of the protein it encodes, can extend the lifespan of flies.

    • Kim Baumann
  • Research Highlight |

    Young and colleagues show that anti-cancer compounds can undergo partitioning into biomolecular condensates, affecting their activity.

    • Paulina Strzyz
  • Research Highlight |

    A non-catalytic function of PRC1 is required for chromatin interactions that can facilitate developmental gene activation.

    • Eytan Zlotorynski
  • Research Highlight |

    Premalignant skin stem cells become dependent on extracellular serine for proliferation, and this metabolic reprogramming inhibits tumour-suppressing cell differentiation.

    • Kim Baumann
  • Comment |

    Hans Clevers discusses the value of organoids as an experimental platform for understanding the biology of novel viruses.

    • Hans Clevers
  • Research Highlight |

    Bass and colleagues uncover a role for NAD+ in preventing age-related decline in circadian function in mice.

    • Paulina Strzyz
  • Research Highlight |

    A group of endogenous 22-nucleotide siRNAs, which is produced by Dicer-like 2 proteins, represses translation and contributes to plant adaptation to environmental stress.

    • Kim Baumann
  • Journal Club |

    Ilya Levental outlines maturation of the concept of lipid rafts as an organizational principle of biomembranes.

    • Ilya Levental
  • Research Highlight |

    Mitochondrial fission at plasma membrane wounds induces local signalling via mitochondria-derived reactive oxygen species for membrane repair.

    • Paulina Strzyz
  • Research Highlight |

    The histone acetylation oncoprotein BRD4-NUT helps establish a nuclear subcompartment that supports high levels of gene expression.

    • Eytan Zlotorynski
  • Research Highlight |

    A new study in Molecular Cell shows that human mitochondrial DNA is enriched for the DNA modification N6-methyldeoxyadenosine, which can repress mitochondrial gene expression and regulate the transcriptional response to mitochondrial stress.

    • Joseph Willson
  • Research Highlight |

    In their study in Cell Liang et al. identify 200 regulators of ER-phagy and specifically dissect the role of mitochondrial oxidative metabolism and protein UFMylation in promoting ER-phagy.

    • Paulina Strzyz
  • Research Highlight |

    Tau post-translational modifications and their crosstalk contribute to the formation of disease-specific intracellular tau aggregates.

    • Kim Baumann
  • Research Highlight |

    Defective mitochondria in senescent cells activate a signalling pathway that promotes the senescence-associated secretory phenotype and inflammation.

    • Eytan Zlotorynski
  • Research Highlight |

    A new study in Science shows that AMPK is an inhibitor of caspase 6-driven hepatic cell death in non-alcoholic steatohepatitis.

    • Paulina Strzyz