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The biogenesis of multivesicular endosomes

Nature Reviews Molecular Cell Biology volume 5, pages 317–323 (2004)Cite this article

Abstract

Recent progress has been made in our understanding of the molecular mechanisms that regulate the biogenesis of multivesicular transport intermediates in the degradation pathway that leads to lysosomes. Here, we discuss recent work that uncovers some of the mechanisms that cause both membrane invagination within these newly forming intermediates and the detachment of these intermediates from early endosomal membranes.

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Figure 1: The degradation (multivesicular) pathway that leads to lysosomes.
Figure 2: Ultrastructure of endosomes after HRS or annexin-II downregulation.
Figure 3: The ECV/MVB-related functions of HRS and annexin-II.

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Acknowledgements

H.S. is supported by the Norwegian Cancer Society and the Research Council of Norway, and J.G. by the Swiss National Science Foundation and the Human Frontier Science Programme Organization.

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Authors and Affiliations

  1. the Department of Biochemistry, University of Geneva, 30 quai Ernest Ansermet, 1211-Geneva-4, Switzerland

    Jean Gruenberg

  2. Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital, Montebello, Oslo, N-0310, Norway

    Harald Stenmark

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Related links

Related links

DATABASES

Interpro

FYVE domain

PX domain

LocusLink

ANXA2

VPS34

Saccharomyces genome database

Fab1

Vps4

Vps10

Vps23

Vps36

Vps37

Swiss-Prot

EGFR

HRS

LAMP1

LAMP2

PIKFYVE

TSG101

FURTHER INFORMATION

Jean Gruenberg's laboratory

Harald Stenmark's laboratory

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Gruenberg, J., Stenmark, H. The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol 5, 317–323 (2004). https://doi.org/10.1038/nrm1360

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