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DNA N6-adenosine methylation is a transgenerational epigenetic modification that confers mitochondrial stress adaptation in the nematode Caenorhabditis elegans.
The RNA-binding protein TIS11B forms a membraneless organelle, the TIS granule, in an endoplasmic reticulum (ER) subdomain termed the TIS granule–ER (TIGER) domain, which facilitates 3ʹ UTR-mediated protein–protein interactions that regulate protein trafficking.
Transcription elongation supported by the super elongation complex, and H3K9 methylation and gene repression by G9a mediate the oncogenic function of Myc.
DNA double-strand breaks at active genes are repaired by a dedicated homologous recombination mechanism involving R-loop formation and RAD52 recruitment.
3′uridylation by TUT4 and TUT7 is shown as a post-transcriptional mechanism restricting retrotransposition of LINE-1 elements and also replication of animal RNA viruses.
A study reports that CRISPR–Cas9 induces extensive on-target mutagenesis in mouse and human cells, calling for greater caution when using it in clinical contexts.
Poly(dA:dT) tracts characterize strong DNA replication origins in mammals and cause replication-fork collapse and DNA breaks that underlie the expression of fragile sites.
A new study in Nature identifies a molecular axis linking diabetes to cancer, whereby AMPK, which is inhibited in high glucose conditions, regulates the stability of TET2 DNA demethylase, thereby impacting DNA methylation and gene expression.