Research Highlights in 2010

A new link between transcription and translation mediated by Rpb4–Rpb7.

Defining the stepwise mechanisms of spindle disassembly.

Specialized endosomal tubules regulate sequence-specific recycling.

Ubiquitin ligases for distinct proteolytic pathways cooperate to enhance substrate ubiquitylation.

LKB1 maintains HSC homeostasis.

Describes a synthetic RNA-based device that can reprogramme cell signalling.

Super-resolution light microscopy reveals ultrastructural architecture of focal adhesions.

Primary cilia under fluid flow downregulate mTOR signalling to inhibit cell size.

SETD8 degradation is mediated by CRL4^CDT2.

Identification of a pathway for ATM activation that is dependent on oxidative stress.

ILK directs a pathway that mediates caveolar trafficking by microtubules.

Piwi-interacting RNAs can regulate embryonic patterning by controlling Nanos mRNA decay.

A new sumoylation mechanism for regulating RAC1 activity.

Reveals how Patronin caps and stabilizes microtubule minus ends.

Identification of Hos1 as the deacetylase for the cohesin component Smc3.

Intestinal stem cells divide symmetrically and stochastically adopt stem or differentiating fates.

Ubiquitin chain trimming by USP14 inhibits protein degradationin vitro and in vivo.

PARP1 acts in a pathway that links feeding to control of peripheral clocks.

HMGB1 is a crucial regulator of autophagy.