Research Highlights

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  • Kawaguchi et al. identify a chromatin code based on repressive histone 3 lysine 27 trimethylation (H3K27me3) that serves as a segment-specific positional marker in connective tissue cells of axolotls, enabling correct patterning during limb regeneration.

    • Lisa Heinke
    Research Highlight
  • Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosis following bacterial infection.

    • Lisa Heinke
    Research Highlight
  • This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.

    • Kim Baumann
    Research Highlight
  • The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. describe a novel assembly factor that evolved during the terrestrialization of land plants.

    • Lisa Heinke
    Research Highlight
  • In mouse models of acute kidney injury, the outcome — scarless tissue repair versus fibrosis — depends on the activity of the transcription factor SOX9.

    • Kim Baumann
    Research Highlight
  • Rapid reactivation of gene expression following mitosis-induced silencing is facilitated by a network of redundantly acting nuclear receptors that function as mitotic bookmarks.

    • Lisa Heinke
    Research Highlight
  • Farmer et al. show that mRNAs encoding abscission proteins are targeted to the midbody during cell division and are locally translated to enable cytokinesis.

    • Lisa Heinke
    Research Highlight
  • Cell quiescence dampens mTOR signalling and enables AGO2 localization to the nucleus, where it suppresses retrotransposons by directly cleaving their RNA.

    • Eytan Zlotorynski
    Research Highlight
  • Phosphorylation of the mitochondrial DNA (mtDNA) maintenance factor TFAM during spermatogenesis prevents its import into mitochondria, resulting in elimination of paternal mtDNA and leading to maternal inheritance.

    • Eytan Zlotorynski
    Research Highlight
  • Congratulations to John Jumper and Demis Hassabis for winning the 2023 Albert Lasker Basic Medical Research Award.

    • Paulina Strzyz
    Research Highlight
  • To activate noncanonical LC3B lipidation and NLRP3 inflammasome formation, stimulator of interferon genes (STING) forms a proton channel in Golgi membranes.

    • Lisa Heinke
    Research Highlight
  • In the amphibian axolotl, the kinase mTOR is hyper-sensitive and activates a protein synthesis response that is crucial for wound healing and tissue regeneration.

    • Eytan Zlotorynski
    Research Highlight