Research Highlights

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  • Organelles are normally transmitted to progeny exclusively through the maternal germ line. Chung et al. now describe genetic and environmental factors that increase the inheritance of plastids through pollen.

    • Lisa Heinke
    Research Highlight
  • The increased expression of certain human endogenous retroviruses induces the cGAS–STING pathway and drives cell senescence and ageing.

    • Eytan Zlotorynski
    Research Highlight
  • Early zebrafish embryos increase the size and complexity of their nuclear pore complexes, enabling efficient nuclear import of maternal transcription factors, which induces zygotic genome activation.

    • Eytan Zlotorynski
    Research Highlight
  • Zhang et al. report that angiogenesis in the chick embryo is supported by migrasomes — recently described organelles produced by migrating cells.

    • Paulina Strzyz
    Research Highlight
  • Cockburn et al. report that cells exiting the epidermal stem cell layer show a gradual progression of transcriptional changes during differentiation and retain the ability to divide once differentiation-committed.

    • Lisa Heinke
    Research Highlight
  • The oncoprotein MYC undergoes multimerization to limit transcription–replication conflicts, thereby reducing the formation of DNA double-strand breaks in cancer cells.

    • Eytan Zlotorynski
    Research Highlight
  • Bera et al. demonstrate that increased viscosity of the surrounding fluid promotes cell migration, supporting tumour cell dissemination and tissue colonization in vivo.

    • Paulina Strzyz
    Research Highlight
  • Malka et al. uncover thousands of 5′ uncapped and polyadenylated transcripts (5′ UPTs) and describe their biogenesis through the alternative polyadenylation pathway. 5′ UPTs contribute to the proteome as non-canonical peptides with likely diverse biological functions.

    • Lisa Heinke
    Research Highlight
  • Reyes et al. show that fibroblasts with properties of cellular senescence are present in healthy epithelial tissues and — by upregulating the senescence associated secretory phenotype (SASP) — they support stem-cell function and tissue repair.

    • Paulina Strzyz
    Research Highlight
  • Zheng et al. show that calcium transients at the endoplasmic reticulum surface trigger condensation of FIP200 and the formation of ULK1 assemblies for autophagosome biogenesis.

    • Paulina Strzyz
    Research Highlight
  • DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is important for replication-fork reversal under replication stress, and its inhibition can abolish PARP-inhibitor resistance in cancer cells.

    • Eytan Zlotorynski
    Research Highlight
  • Kalkavan et al. show how drug-tolerant persister cells evade apoptosis by release of sublethal cytochrome c and activation of the integrated stress response.

    • Michael Attwaters
    Research Highlight
  • Steinhorst et al. show how calcium signal induced by salt stress is ‘decoded’ by plant roots to provide systemic response and to increase salt tolerance.

    • Paulina Strzyz
    Research Highlight
  • Cheng, Mittnenzweig et al. demonstrate the cellular role of the major DNA demethylation machinery, ten-eleven translocation (TET) dioxygenases, in early mammalian development.

    • Paulina Strzyz
    Research Highlight
  • Kirova et al. demonstrate that reactive oxygen species signals are integrated into cell cycle control through a direct interaction with cyclin-dependent kinase 2.

    • Lisa Heinke
    Research Highlight
  • Sladitschek-Martens show that reduced activity of key cellular mechanosensors, transcription co-activators YAP/TAZ, is an important driver of ageing of stromal and contractile cells, leading to cell senescence.

    • Paulina Strzyz
    Research Highlight