Research Highlights

Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosis following bacterial infection.

This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.

The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. describe a novel assembly factor that evolved during the terrestrialization of land plants.

In mouse models of acute kidney injury, the outcome — scarless tissue repair versus fibrosis — depends on the activity of the transcription factor SOX9.

Harmful activity of the DNA sensor cGAS in the nucleus is suppressed by a dedicated ubiquitylation complex.

A recent study visualizes how enhancer–transcriptional condensate–gene interactions augment gene expression.

Rapid reactivation of gene expression following mitosis-induced silencing is facilitated by a network of redundantly acting nuclear receptors that function as mitotic bookmarks.

Farmer et al. show that mRNAs encoding abscission proteins are targeted to the midbody during cell division and are locally translated to enable cytokinesis.

Cell quiescence dampens mTOR signalling and enables AGO2 localization to the nucleus, where it suppresses retrotransposons by directly cleaving their RNA.

Yu et al. identify senescent cells as important players in the regeneration of complex structures.

Phosphorylation of the mitochondrial DNA (mtDNA) maintenance factor TFAM during spermatogenesis prevents its import into mitochondria, resulting in elimination of paternal mtDNA and leading to maternal inheritance.

mTOR inhibition by deprivation of the amino acids Tyr, Trp and Phe promotes the translocation of the 26S proteasome from the nucleus to the cytosol, which is required for stress tolerance and cell survival.

Sarkar et al. identify a feedback loop between the methyltransferase SETDB1 and nuclear pore complexes that ensures silencing of early-oogenesis genes as oocyte specification progresses.

Congratulations to John Jumper and Demis Hassabis for winning the 2023 Albert Lasker Basic Medical Research Award.

Liang et al. show that mitochondria can be expelled from cells via extracellular vesicles as a route of quality control that is an alternative to lysosomal degradation.

To activate noncanonical LC3B lipidation and NLRP3 inflammasome formation, stimulator of interferon genes (STING) forms a proton channel in Golgi membranes.

In the amphibian axolotl, the kinase mTOR is hyper-sensitive and activates a protein synthesis response that is crucial for wound healing and tissue regeneration.

Cremer et al. show that the ubiquitin ligase RNF26 and vimentin-based intermediate filaments cooperate to control perinuclear ER membrane organization and thus facilitate recovery from ER stress.

Cycles of stretch and compression, such as during cell migration through tissues, lead to stabilization of microtubules owing to redistribution of the plus-end-binding protein CLASP2 along microtubule lengths.

Transcription factors bind RNA through an Arg-rich motif; these interactions potentially promote transcription and development, and their dissociation can contribute to disease.