Research Highlights

  • Research Highlight |

    Wilfling et al. report a previously undescribed selective autophagy pathway that removes aberrant intermediates of clathrin-mediated endocytosis.

    • Paulina Strzyz
  • Research Highlight |

    RNA editing by ADAR1 destabilizes epigenetic-treatment-induced retrotransposon stem–loops and thus dampens the immune response to the treatment, suggesting that ADAR1 could be a therapeutic target in combination with epigenetic therapy.

    • Eytan Zlotorynski
  • Research Highlight |

    The discovery of the CRISPR–Cas9 system by Emmanuelle Charpentier and Jennifer Doudna awarded a 2020 Nobel Prize in Chemistry.

    • Paulina Strzyz
  • Research Highlight |

    A signalling pathway comprising TMO5–LHW and cytokinin controls plant adaptation to low-phosphate levels in the soil by increasing root hair density.

    • Eytan Zlotorynski
  • Research Highlight |

    Wozniak and colleagues reveal that cleavage of the lysosomal protein RILP following activation of the inflammasome enhances exosome release and regulates the trafficking of miRNAs into exosomes by FMR1.

    • Joseph Willson
  • Research Highlight |

    The switch from glycolytic metabolism to OXPHOS functions as a driver of cell immortalization during tumorigenesis in the fly brain.

    • Paulina Strzyz
  • Research Highlight |

    The role of chromosome clustering as a driver of nucleo-cytoplasmic compartmentalization after mitosis.

    • Paulina Strzyz
  • Research Highlight |

    A new study demonstrates that glypicans shield the palmitoleate on WNTs to enable their distribution in tissues.

    • Paulina Strzyz
  • Research Highlight |

    DPPA2 and DPPA4 maintain promoter bivalency and low levels of DNA methylation at certain lineage-specific genes.

    • Eytan Zlotorynski
  • Research Highlight |

    Vietri et al. show that failure to repair micronuclear membranes is caused by unrestrained activity of ESCRT-III.

    • Paulina Strzyz
  • Research Highlight |

    Increased expression of the circular RNA generated by the sulfateless gene (circSfl), and of the protein it encodes, can extend the lifespan of flies.

    • Kim Baumann
  • Research Highlight |

    Young and colleagues show that anti-cancer compounds can undergo partitioning into biomolecular condensates, affecting their activity.

    • Paulina Strzyz
  • Research Highlight |

    A non-catalytic function of PRC1 is required for chromatin interactions that can facilitate developmental gene activation.

    • Eytan Zlotorynski
  • Research Highlight |

    Premalignant skin stem cells become dependent on extracellular serine for proliferation, and this metabolic reprogramming inhibits tumour-suppressing cell differentiation.

    • Kim Baumann
  • Research Highlight |

    Bass and colleagues uncover a role for NAD+ in preventing age-related decline in circadian function in mice.

    • Paulina Strzyz
  • Research Highlight |

    A group of endogenous 22-nucleotide siRNAs, which is produced by Dicer-like 2 proteins, represses translation and contributes to plant adaptation to environmental stress.

    • Kim Baumann
  • Research Highlight |

    Mitochondrial fission at plasma membrane wounds induces local signalling via mitochondria-derived reactive oxygen species for membrane repair.

    • Paulina Strzyz
  • Research Highlight |

    The histone acetylation oncoprotein BRD4-NUT helps establish a nuclear subcompartment that supports high levels of gene expression.

    • Eytan Zlotorynski
  • Research Highlight |

    A new study in Molecular Cell shows that human mitochondrial DNA is enriched for the DNA modification N6-methyldeoxyadenosine, which can repress mitochondrial gene expression and regulate the transcriptional response to mitochondrial stress.

    • Joseph Willson
  • Research Highlight |

    In their study in Cell Liang et al. identify 200 regulators of ER-phagy and specifically dissect the role of mitochondrial oxidative metabolism and protein UFMylation in promoting ER-phagy.

    • Paulina Strzyz
  • Research Highlight |

    Tau post-translational modifications and their crosstalk contribute to the formation of disease-specific intracellular tau aggregates.

    • Kim Baumann
  • Research Highlight |

    Defective mitochondria in senescent cells activate a signalling pathway that promotes the senescence-associated secretory phenotype and inflammation.

    • Eytan Zlotorynski
  • Research Highlight |

    A new study in Science shows that AMPK is an inhibitor of caspase 6-driven hepatic cell death in non-alcoholic steatohepatitis.

    • Paulina Strzyz
  • Research Highlight |

    In cells exposed to stiff extracellular matrix, sequestration of the ubiquitin ligase TRIM21 by actin stress fibres can prevent the ubiquitination and breakdown of the glycolytic enzyme PFK, directly linking mechanical sensing to metabolic regulation.

    • Joseph Willson
  • Research Highlight |

    DIX domains ― found in the plant SOSEKI proteins ― have a conserved role in enabling concentration-dependent protein polymerization and the assembly of cell polarity complexes.

    • Kim Baumann
  • Research Highlight |

    Extopic expression of the XIST RNA at one chromosome 21 in iPSCs derived from individuals with Down syndrome leads to transcriptional silencing of chromosome 21 and improves iPSC differentiation into neurons.

    • Minju Ha
  • Research Highlight |

    ECM of tendons harbours collagen fibres that are continuously remodelled in a circadian fashion.

    • Paulina Strzyz
  • Research Highlight |

    The tissue culture bottleneck for gene editing in plants can be overcome by modifying somatic cells in whole plants and inducing the formation of shoot meristems.

    • Kim Baumann
  • Research Highlight |

    During spermiogenesis, piRNAs are the core of a complex that selects mRNAs for translation activation

    • Eytan Zlotorynski
  • Research Highlight |

    Infection with RNA viruses of the Flaviviridae family leads to changes in the methylation of host mRNAs that are driven by induction of innate immunity and endoplasmic reticulum stress

    • Caroline Barranco
  • Research Highlight |

    Catalytically inactive caspase 8 can activate pyroptosis when apoptosis and necroptosis are blocked, a potential line of defence against viruses that inhibit cell death.

    • Joseph Willson
  • Research Highlight |

    The Integrator complex fine-tunes mRNA levels in response to stress by attenuating productive transcription elongation

    • Marzia Munafò
  • Research Highlight |

    Nutrient status is uncoupled from the control of autophagy during mitosis through a switch from mTORC1- to CDK1-mediated inhibition of autophagy regulators.

    • Joseph Willson
  • Research Highlight |

    Compounds that tether toxic proteins with polyglutamine expansions to autophagosomes promote their autophagic clearance and might, in principle, be suitable for the treatment of associated neurodegenerative diseases.

    • Kim Baumann
  • Research Highlight |

    CRISPR–Cas9-based prime editing supports the correction of a wide range of mutations, including transversions and insertions and deletions.

    • Eytan Zlotorynski
  • Research Highlight |

    Mitochondrial DNA damage causes ageing by having a negative effect on nuclear DNA replication and genome integrity.

    • Kim Baumann
  • Research Highlight |

    G-quadruplex-containing RNA binds PRC2, removes it from chromatin and activates gene expression.

    • Katharine H. Wrighton
  • Research Highlight |

    Efficient mRNA trafficking is supported by tethering of RNA granules to motile lysosomes through ANXA11.

    • Paulina Strzyz
  • Research Highlight |

    A demonstration of a physiological role of amyloid aggregates in switching on enzymatic activity required for fly development.

    • Paulina Strzyz
  • Research Highlight |

    Demonstration that active collective cell migration importantly contributes to the movement of intestinal epithelial cells along the villi.

    • Paulina Strzyz
  • Research Highlight |

    Cytosine methylation (m5C) in mRNAs is important for their transport to distant tissues in plants.

    • Kim Baumann
  • Research Highlight |

    Ubiquitin ligase parkin — a key mediator of mitophagy — is induced in necroptotic conditions through the activity of AMP-activated protein kinase (AMPK) to restrain necroptosis and limit associated pathologies.

    • Paulina Strzyz