Research Highlights

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  • An amino acid substitution found in a ribosomal protein in archaea can increase translation fidelity and lifespan in metazoans.

    • Eytan Zlotorynski
    Research Highlight
  • Xu et al. report engineering a compact version of Cas that can be useful for a broad range of genome engineering applications in mammalian cells.

    • Paulina Strzyz
    Research Highlight
  • Tau oligomers bind to m6A-modified RNA transcripts in the cytoplasm via the linker RNA-binding protein HNRNPA2B1; such complexes are found in individuals with Alzheimer disease and are part of a stress response that represses translation.

    • Kim Baumann
    Research Highlight
  • Garabedian et al. developed designer biomolecular condensates serving as tools for flexible interrogation and temporal regulation of cell functions.

    • Paulina Strzyz
    Research Highlight
  • Suppressing ovulation protects against chromosomal abnormalities in ageing mouse oocytes, which can be partly explained by increasing REC8–cohesin retention on chromosomes.

    • Kim Baumann
    Research Highlight
  • RNA interference mediated by a Dicer isoform protects mammalian stem cells against RNA viruses.

    • Eytan Zlotorynski
    Research Highlight
  • The pathogenicity of SARS-CoV-2 and respiratory syncytial virus (RSV) involves mechanisms of liquid–liquid phase separation, which can be explored as targets for new antiviral therapeutics.

    • Paulina Strzyz
    Research Highlight
  • Apoptotic hair follicle stem cells contribute to tissue regeneration by producing WNT3, which promotes cell proliferation, enlarging the stem cell pool.

    • Kim Baumann
    Research Highlight
  • Torrino et al. show that the stiffness of the extracellular matrix regulates microtubule posttranslational modification via glutamylation, which impacts microtubule dynamics and cell invasiveness.

    • Paulina Strzyz
    Research Highlight
  • Nuclear condensates of m6A-methylated mRNAs with their ‘reader’ YTHDC1 prevent the degradation of acute myeloid leukaemia-promoting mRNAs by the exosome.

    • Eytan Zlotorynski
    Research Highlight
  • The transcription factor p53 boosts the expression of a distinct subset of its target genes by enhancing their association with nuclear speckles.

    • Eytan Zlotorynski
    Research Highlight
  • Roney et al. show that neuronal loss in Niemann-Pick disease type C is associated with the impairment of lysosome trafficking by cholesterol that accumulates on lysosome membranes.

    • Paulina Strzyz
    Research Highlight
  • Unexpected high levels of recurrent DNA single-strand break repair were detected in enhancer regions of post-mitotic neurons.

    • Kim Baumann
    Research Highlight
  • Lancaster and colleagues describe a morphological change in early primate brain stem cells, the timing of which could underlie the differences in brain size between human and apes.

    • Paulina Strzyz
    Research Highlight
  • Moore et al. show the role of actin assemblies in regulating the balanced distribution of a healthy mitochondrial network between daughter cells in mitosis.

    • Paulina Strzyz
    Research Highlight