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Sally Lowell discusses the concept of ‘community effect’ when cells commit to a certain differentiation path, which was proposed by John Gurdon in 1988 and recently suggested to enable cancer cells to gain control.
Twenty years ago it was reported that epithelial–mesenchymal transition (EMT), a key developmental process, occurs in cancer; many studies have since, and still are, studying EMT heterogeneity and its functional implications.
Although the organization of cell membranes into lipid rafts has become a key concept in cell biology, how partitioning of membrane components into subdomains is achieved remains an important question.
In this Journal Club, Audrey Williams and Sally Horne-Badovinac highlight the importance of studying the basal cell surface and its dynamics to understand epithelial cell behaviours and tissue rearrangements.
Senescent cells secrete a multitude of factors that modulate their local environment — a phenomenon known as senescence-associated secretory phenotype (SASP). David Bernard highlights that the SASP secretome can be flexibly regulated, resulting in different types of SASP, which contributes to the versatility of responses triggered by senescent cells.
Kikuë Tachibana discusses some of the key findings of the seminal works of Sir John Gurdon on nuclear reprogramming and how, by being examples of scientific rigour, they have inspired her own research.
Philip Cohen highlights how two studies from the laboratory of Zhijian Chen, published in 2000 and 2001, started a new era in the study of signal transduction pathways and the roles of ubiquitin chains.
Daniel Gerlich discusses how a study by the Hyman laboratory introduced the theory of liquid phase separation to cell biology and its implications for the understanding of cell organization and function.
Allan Jacobson reminds us of how a study by Deveret al. published in 1992 connected several data on translational regulation, bringing attention to its crucial role in the regulation of gene expression.