Journal Clubs

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  • Journal Club |

    Giancarlo Abis recounts his inspiration for becoming a structural biologist — the publication of the HIV-1 RT structure, which enabled a therapeutic breakthrough.

    • Giancarlo Abis
  • Journal Club |

    A 2017 paper showed that phase separation and formation of elastin in the extracellular matrix does not require protein secondary structures, but cross-linked disordered chains.

    • Nicolas Lux Fawzi
  • Journal Club |

    Gavin Kelsey discusses the first reports of genomic imprinting in mammals and how they raised the profile of epigenetics in the study of mammalian development.

    • Gavin Kelsey
  • Journal Club |

    Twenty years ago it was reported that epithelial–mesenchymal transition (EMT), a key developmental process, occurs in cancer; many studies have since, and still are, studying EMT heterogeneity and its functional implications.

    • M. Angela Nieto
  • Journal Club |

    Although the organization of cell membranes into lipid rafts has become a key concept in cell biology, how partitioning of membrane components into subdomains is achieved remains an important question.

    • Anne K. Kenworthy
  • Journal Club |

    Roland Wenger highlights discovery of HIFs and recent insights into their differential physiological roles.

    • Roland H. Wenger
  • Journal Club |

    Ana García-Sáez highlights the continued interest in BCL-2 proteins and their mechanisms.

    • Ana J. García-Sáez
  • Journal Club |

    Ilya Levental outlines maturation of the concept of lipid rafts as an organizational principle of biomembranes.

    • Ilya Levental
  • Journal Club |

    In this Journal Club, Audrey Williams and Sally Horne-Badovinac highlight the importance of studying the basal cell surface and its dynamics to understand epithelial cell behaviours and tissue rearrangements.

    • Audrey M. Williams
    •  & Sally Horne-Badovinac
  • Journal Club |

    Lluís Ribas de Pouplana outlines the unanswered questions of mitochondrial transcription.

    • Lluís Ribas de Pouplana
  • Journal Club |

    Dan Mishmar recounts the first studies that used mitochondrial DNA (mtDNA) to trace the origin of humanity to Africa and that connected mtDNA mutations with a human disease.

    • Dan Mishmar
  • Journal Club |

    Marianne Farnebo describes how the application of microscopy techniques has provided valuable information on repeats RNAs.

    • Marianne Farnebo
  • Journal Club |

    Emil Heitz was a pioneer of epigenetics at a time when the nature of the heredity material was still unclear.

    • Frédéric Berger
  • Journal Club |

    Early in his career, Gordon Carmichael was inspired by the contradictory conclusions of three articles.

    • Gordon Carmichael
  • Journal Club |

    Arnaud Echard discusses two studies that uncovered a key role for the ESCRT machinery in cytokinesis.

    • Arnaud Echard
  • Journal Club |

    Henrik Jönsson discusses the mathematical model for hormone movement through plant tissues that Graeme Mitchison proposed in 1980, and how models can inspire new research.

    • Henrik Jönsson
  • Journal Club |

    Susana Godinho discusses a 1996 paper by Heald et al. on the organization of microtubules into bipolar spindles.

    • Susana A. Godinho
  • Journal Club |

    Jesús Gil discusses the first evidence for cellular senescence being associated with ageing, and how these studies opened new routes for basic and translational research.

    • Jesús Gil
  • Journal Club |

    Channing Der and Kirsten Bryant discuss recent work leading towards therapeutic targeting of autophagy in pancreatic cancer.

    • Kirsten L. Bryant
    •  & Channing J. Der
  • Journal Club |

    David Barford discusses how the template model for MAD2 activation in the spindle assembly checkpoint represented a new concept for generating and propagating intracellular signals.

    • David Barford
  • Journal Club |

    Adriano Aguzzi discusses the endeavours of the Gitler team to identify the causes underlying the fatal human neurological disease amyotrophic lateral sclerosis (ALS).

    • Adriano Aguzzi
  • Journal Club |

    The introduction of DNA-chain terminators for sequencing by Fred Sanger enabled the early genome sequencing projects.

    • George G. Brownlee
  • Journal Club |

    Ueli Schibler explains why the phenotype of a mutation in a codon of the ‘21st amino acid’ selenium cysteine was unexpectedly specific.

    • Ueli Schibler
  • Journal Club |

    Rebecca Taylor discusses the elegance and importance of early discoveries from the Walter laboratory on the unfolded protein response, and why they have become landmark studies.

    • Rebecca C. Taylor
  • Journal Club |

    Senescent cells secrete a multitude of factors that modulate their local environment — a phenomenon known as senescence-associated secretory phenotype (SASP). David Bernard highlights that the SASP secretome can be flexibly regulated, resulting in different types of SASP, which contributes to the versatility of responses triggered by senescent cells.

    • David Bernard
  • Journal Club |

    Kikuë Tachibana discusses some of the key findings of the seminal works of Sir John Gurdon on nuclear reprogramming and how, by being examples of scientific rigour, they have inspired her own research.

    • Kikuë Tachibana
  • Journal Club |

    Philip Cohen highlights how two studies from the laboratory of Zhijian Chen, published in 2000 and 2001, started a new era in the study of signal transduction pathways and the roles of ubiquitin chains.

    • Philip Cohen
  • Journal Club |

    Eva Nogales looks back at the early days of structure determination of cytoskeletal components.

    • Eva Nogales
  • Journal Club |

    Navdeep Chandel highlights a study published in 1996 that — by showing that mitochondria can release cytochromecto initiate apoptosis — changed his view of the role of mitochondria in physiology.

    • Navdeep S. Chandel
  • Journal Club |

    Christopher Chen highlights the early studies of mechanoregulation of cell–matrix adhesions that established mechanobiology as a cross-discplinary research field

    • Christopher S. Chen
  • Journal Club |

    Daniel Gerlich discusses how a study by the Hyman laboratory introduced the theory of liquid phase separation to cell biology and its implications for the understanding of cell organization and function.

    • Daniel W. Gerlich
  • Journal Club |

    A modification of Meselson and Stahl's density gradient centrifugation method and a rare Texan yeast helped show that eukaryotic ribosomes dissociate and reform during translation.

    • Raymond Kaempfer
  • Journal Club |

    Thomas D. Pollard discusses the early work of Thompson and Wolpert on cytoplasmic extract from amoebae, which laid the foundation for studies of actin-driven cell motility.

    • Thomas D. Pollard
  • Journal Club |

    Kai Simons discusses how MDCK cells grown on semi-permeable filters have become a model for studying apico-basal cell polarity with the use of viruses.

    • Kai Simons
  • Journal Club |

    Li and Lodish describe how a shift in our understanding of the molecular basis of sickle cell anaemia has led to clinical success.

    • Hojun Li
    •  & Harvey Lodish
  • Journal Club |

    Caroline Dean discusses the mechanisms underlying the storage and inheritance of epigenetic memory.

    • Caroline Dean
  • Journal Club |

    Edith Heard describes how the discovery of lamina-associated domains changed her thinking about the mechanisms of X-chromosome inactivation and gene regulation.

    • Edith Heard
  • Journal Club |

    Physically bridging an enhancer to a β-globin gene increased transcription and explained how enhancers could function over long distances.

    • Peter Fraser
  • Journal Club |

    Matthias Mann describes a 1992 paper by Donald Hunt and colleagues that revolutionized the use of mass spectrometry in molecular biology.

    • Matthias Mann