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In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of cellular senescence and its effect on physiology and ageing, shaping the future of this research field.
Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the importance of RNA transport for development.
Emily Wong describes a study that provided a quantitative methodology for analyzing ChIP experiments and shifted our understanding of the functionality of transcription factors.
Ernst and Renne highlight two papers, one that discovered and another that structurally defined the ER–mitochondria encounter structure (ERMES) that facilitates the exchange of lipids between the ER and mitochondria.
Antennapedia proteins were among the first proteins found to be exchanged intercellularly. This discovery by Alain Prochiantz and colleagues has inspired researchers of various backgrounds.
Bulut-Karslıoğlu remembers the publication of two seminal papers that described bivalent chromatin and how this discovery continues to affect research to this day.
Anne West recounts the study that showed postnatal accumulation of non-CpG DNA methylation in neurons coinciding with postnatal synapse maturation, suggesting that it contributes to brain function.
The discovery that peripheral organs such as the spleen support blood formation following radiation has inspired haematology research for over five decades.