Journal Clubs

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  • Chiara Zurzolo brings to attention the pioneering work that established virus-infected cells as a model to study cell polarity.

    • Chiara Zurzolo
    Journal Club
  • Rashmi Sasidharan highlights the work by Musgrave et al. (1972) demonstrating that ethylene drives shoot elongation in plants submerged in water, allowing the plant to outgrow the floodwaters.

    • Rashmi Sasidharan
    Journal Club
  • Marta Shahbazi recounts the work by Lewis and Rossant (1982) that pioneered research on size regulation in mammalian embryos.

    • Marta N. Shahbazi
    Journal Club
  • Luciano Marcon discusses the revolutionary work by Alan Turing proposing that embryogenesis could be entirely a self-organizing process.

    • Luciano Marcon
    Journal Club
  • Elvan Böke recounts the pioneering work of Arthur T. Hertig on the ultrastructure of human oocytes.

    • Elvan Böke
    Journal Club
  • Hiroshide Saito discusses two seminal papers that provided foundational evidence for the hypothesis that RNA with both genetic information and catalytic activity had an essential role in the origin of life.

    • Hirohide Saito
    Journal Club
  • Olivia Rissland recounts the findings of a paper that was seminal to our understanding of mRNA decay.

    • Olivia S. Rissland
    Journal Club
  • James Olzmann discusses the groundbreaking work of Ron Kopito and colleagues, which demonstrated that a CFTR mutant is ubiquitinated and degraded by the cytosolic 26S proteasome. This discovery contributed to our understanding of ERAD and had important implications for the development of therapeutic agents for cystic fibrosis.

    • James A. Olzmann
    Journal Club
  • Kate Meyer reminds us of a study of mRNA N6-methyladenosine that predated the epitranscriptomics era by decades.

    • Kate D. Meyer
    Journal Club
  • Heterochromatin DNA is heavily methylated yet also inaccessible. Olivier Mathieu describes the work that revealed how DNA methyltransferases access heterochromatin.

    • Olivier Mathieu
    Journal Club
  • Transposons and their host genomes are entangled in an evolutionary arms race, recounts Tuğçe Aktaş.

    • Tuğçe Aktaş
    Journal Club
  • Ting and Lee describe how the trypanosome base J ‘inspired’ the discovery of the mechanism of active DNA demethylation.

    • Angela H. Ting
    • Byron H. Lee
    Journal Club
  • Keren Lasker discusses early work of Lucy Shapiro, which provided first evidence that bacterial cells spatially regulate their cellular processes, akin to their eukaryotic counterparts.

    • Keren Lasker
    Journal Club
  • Valeria Levi recounts how a clever way to visualize the function of H+-ATP synthase pioneered single-molecule technologies.

    • Valeria Levi
    Journal Club
  • ‘Alpha helix’ was not Linus Pauling’s first choice of a name for the protein structural motif. Egli and Zhang recount what the original name was, why it was changed and what is between the alpha helix and the DNA double helix.

    • Martin Egli
    • Shuguang Zhang
    Journal Club
  • Mike Henne discusses the pioneering work of Jean Vance, which revealed that mitochonodria-associated membranes (MAMs) are sites for inter-organelle phospholipid exchange and step-wise synthesis reactions.

    • W. Mike Henne
    Journal Club
  • Appreciation of intrinsically disordered regions of proteins is not a novel phenomenon: Frixione and Ruiz-Zamarripa recollect that they were discussed already in the mid-twentieth century.

    • Eugenio Frixione
    • Lourdes Ruiz-Zamarripa
    Journal Club