Research Highlights

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  • To activate noncanonical LC3B lipidation and NLRP3 inflammasome formation, stimulator of interferon genes (STING) forms a proton channel in Golgi membranes.

    • Lisa Heinke
    Research Highlight
  • In the amphibian axolotl, the kinase mTOR is hyper-sensitive and activates a protein synthesis response that is crucial for wound healing and tissue regeneration.

    • Eytan Zlotorynski
    Research Highlight
  • Cremer et al. show that the ubiquitin ligase RNF26 and vimentin-based intermediate filaments cooperate to control perinuclear ER membrane organization and thus facilitate recovery from ER stress.

    • Paulina Strzyz
    Research Highlight
  • Cycles of stretch and compression, such as during cell migration through tissues, lead to stabilization of microtubules owing to redistribution of the plus-end-binding protein CLASP2 along microtubule lengths.

    • Lisa Heinke
    Research Highlight
  • Transcription factors bind RNA through an Arg-rich motif; these interactions potentially promote transcription and development, and their dissociation can contribute to disease.

    • Eytan Zlotorynski
    Research Highlight
  • Shi et al. show the role of myosin VI in the protection of stalled replication forks during replication stress.

    • Paulina Strzyz
    Research Highlight
  • During cellular stresses, the mRNA internal 7-methylguanosine (m7G) modification is bound by QKI-7, which regulates the stability and/or translation of the mRNAs by sequestering them in stress granules.

    • Eytan Zlotorynski
    Research Highlight
  • Rogers et al. provide evidence that hypoxia is beneficial in mammalian ageing, extending the lifespan of prematurely ageing mice.

    • Paulina Strzyz
    Research Highlight
  • Subunits of the SWI/SNF chromatin remodelling complexes ‘bookmark’ cell-type specifying genes during mitosis to allow their timely reactivation upon mitosis exit.

    • Eytan Zlotorynski
    Research Highlight
  • Transport of the developmental mRNA oskar to its destination at the posterior pole of the Drosophila embryo relies on the two dsRNA-binding proteins Egalitarian and Staufen that promote switching between the motor proteins dynein and kinesin.

    • Lisa Heinke
    Research Highlight
  • A new study collaboratively delivered by Valentina Greco’s and Smita Krishnaswamy’s labs provides new insight into patterns of calcium signalling in epithelial tissues using intravital imaging of the basal layer of the mouse epidermis.

    • Paulina Strzyz
    Research Highlight
  • The eukaryotic genome is organized into topologically associating domains by cohesin and CTCF. Davidson et al. now reveal a role for DNA tension in the regulation of the CTCF–cohesin interaction to modulate domain boundaries.

    • Lisa Heinke
    Research Highlight
  • Cold temperature prolongs lifespan in nematodes by inducing ubiquitin-independent proteasome activity, which prevents protein aggregation and neuronal degeneration. The pathway is conserved in humans.

    • Eytan Zlotorynski
    Research Highlight
  • Shelby et al. demonstrate the existence of discrete domains in plasma membranes of B cells that selectively partition membrane-associated proteins.

    • Paulina Strzyz
    Research Highlight
  • McCarthy et al. identify distinct populations of smooth muscle cells in the intestine that support the establishment of the intestinal stem cell niche during postnatal development by supplying trophic signals to enable niche expansion.

    • Lisa Heinke
    Research Highlight
  • Self-assembly of replication protein A (RPA) into dynamic condensates after binding of single-stranded DNA promotes telomere maintenance in cancer cells.

    • Eytan Zlotorynski
    Research Highlight
  • Weems et al. show that sustained membrane blebbing promotes pro-survival signalling in extracellular matrix-detached cells.

    • Paulina Strzyz
    Research Highlight
  • Scott et al. describe a mechanism based on C-degron mimicry by which an E3 ubiquitin ligase discriminates bona fide substrates from non-physiological substrates.

    • Lisa Heinke
    Research Highlight