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  • Ferroptosis is a non-apoptotic, iron-dependent cell death mechanism driven by plasma membrane lipid peroxidation and subsequent plasma membrane rupture. Various cellular compartments and organelles contribute to regulating susceptibility to ferroptosis. This regulation involves a plethora of mechanisms centred on iron metabolism and storage, lipid metabolism, and redox balance.

    • Scott J. Dixon
    • James A. Olzmann
    Review Article
  • Joana Vidigal reminds us of the first paper to report an endogenous role of the nucleolytic activity of the mammalian RNAi protein argonaute-2.

    • Joana A. Vidigal
    Journal Club
  • Protein S-acylation is involved in many pathophysiological processes. Here, Mesquita et al. discuss the structure, function and regulation of S-acylation and deacylation enzymes and describe how this post-transcriptional modification precisely controls protein–cell membrane interactions. Potential therapeutic applications of S-acylation are also highlighted.

    • Francisco S. Mesquita
    • Laurence Abrami
    • F. Gisou van der Goot
    Review Article
  • In this Tools of the Trade article, Khalid Ibrahim (Radenovic and Lashuel labs) describes a tool for the artificial intelligence (AI)-driven detection of cellular aggregates that bypasses the need for fluorescent labelling.

    • Khalid A. Ibrahim
    Tools of the Trade
  • Rapid reactivation of gene expression following mitosis-induced silencing is facilitated by a network of redundantly acting nuclear receptors that function as mitotic bookmarks.

    • Lisa Heinke
    Research Highlight
  • L. Villiger, J. Joung et al. review CRISPR applications for programmable editing of the genome, epigenome and transcriptome. They discuss how CRISPR–Cas systems can be optimized to further improve editing specificity and efficiency and highlight a multitude of applications in basic biological research and for changing clinical practice.

    • Lukas Villiger
    • Julia Joung
    • Jonathan S. Gootenberg
    Review Article
  • This Review discusses the emerging roles of long non-coding RNAs (lncRNAs) in the regulation of transcription, for example by controlling the expression of transcription factors. Some lncRNA loci function in trans, but most function in cis, through their own transcription or through the lncRNA transcripts themselves.

    • Jorge Ferrer
    • Nadya Dimitrova
    Review Article
  • Farmer et al. show that mRNAs encoding abscission proteins are targeted to the midbody during cell division and are locally translated to enable cytokinesis.

    • Lisa Heinke
    Research Highlight
  • tRNA-derived small RNAs (tdRs) have long been considered mere intermediates of tRNA degradation. This Review discusses the biogenesis and regulation of tdRs and focuses on their emerging gene regulation roles in cell metabolism, immune responses, development and cancer.

    • Sowndarya Muthukumar
    • Cai-Tao Li
    • Cristian Bellodi
    Review Article
  • The Rho GTPases are small GTP binding proteins that regulate basic biological processes such as cell locomotion, cell division and morphogenesis by promoting cytoskeleton-based changes in the cell cortex. These different functions are driven by the ability of Rho GTPases to self-organize, forming diverse spatiotemporal cortical patterns.

    • William M. Bement
    • Andrew B. Goryachev
    • George von Dassow
    Review Article
  • Cell quiescence dampens mTOR signalling and enables AGO2 localization to the nucleus, where it suppresses retrotransposons by directly cleaving their RNA.

    • Eytan Zlotorynski
    Research Highlight
  • Cell death can result from the activation of dedicated programmed cell death machineries or disruption of pro-survival mechanisms. This Review describes the different major mechanisms of cell death and discusses recent insights into their relevance to disease.

    • Junying Yuan
    • Dimitry Ofengeim
    Review Article
  • Scientists are captivated by the prospect of creating a fully synthetic cell, offering the potential to revolutionize biology, medicine and biotechnology. In this Viewpoint, a panel of experts discusses the definitions of a synthetic cell and highlights current achievements, challenges and future opportunities of building such systems.

    • Katarzyna P. Adamala
    • Marileen Dogterom
    • T-Y Dora Tang
    Viewpoint
  • Plant cells assemble a strong yet extensible primary cell wall consisting largely of polysaccharides. Emerging models of wall growth integrate physical properties such as mechanical strength and tension with cellular processes that govern wall loosening and expansion.

    • Daniel J. Cosgrove
    Review Article