Browse Articles

Filter By:

  • This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.

    • Kim Baumann
    Research Highlight
  • The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. describe a novel assembly factor that evolved during the terrestrialization of land plants.

    • Lisa Heinke
    Research Highlight
  • Fibroblasts undergo transient activation into myofibroblasts to restore homeostasis to injured tissues. This Review explores the influence of mechanical cues and epigenetic modifications on (myo)fibroblast activation and memory and discusses potential therapeutic prevention of persistent myofibroblast activation in fibrosis.

    • Fereshteh Sadat Younesi
    • Andrew E. Miller
    • Boris Hinz
    Review Article
  • Imaging of fluorescently labelled nascent RNA in live cells enabled real-time observation of transcription of an endogenous gene.

    • Tineke L. Lenstra
    Journal Club
  • Recent combinations of structure-based and sequence-based calculations and machine learning tools have dramatically improved protein engineering and design. Although designing complex protein structures remains challenging, these methods have enabled the design of therapeutically relevant activities, including vaccine antigens, antivirals and drug-delivery nano-vehicles.

    • Dina Listov
    • Casper A. Goverde
    • Sarel Jacob Fleishman
    Review Article
  • In this Tools of the Trade article, Venkova and Popard (Piel lab) discuss recent updates to the fluorescence exclusion method that now enable simultaneous measurement of cellular and nuclear size as well as investigation of small prokaryotic cells.

    • Larisa Venkova
    • Henri Popard
    Tools of the Trade
  • This Review discusses the complex mechanisms of wound healing — cell migration, matrix remodelling, inflammation and angiogenesis — and the contributions of different cell types, including immune cells, to this process. It also highlights new methodologies that could inform future therapies to prevent scarring and repair chronic wounds.

    • Oscar A. Peña
    • Paul Martin
    Review Article
  • Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the importance of RNA transport for development.

    • Ahna Skop
    • Karen Schindler
    Journal Club
  • The story of a paper that established the concept of codon optimality and its connection with translation efficiency and mRNA decay.

    • Susanne Bornelöv
    Journal Club
  • Methodological advances have enabled discoveries of RNA polymerase interactions with RNA processing machineries, such as the splicing and 3′-end cleavage machineries. This Review discusses the roles of these interactions in gene regulation and eukaryotic cellular stress responses, and highlights parallels between co-transcriptional RNA processing in eukaryotes and prokaryotes.

    • Morgan Shine
    • Jackson Gordon
    • Karla M. Neugebauer
    Review Article
  • In mouse models of acute kidney injury, the outcome — scarless tissue repair versus fibrosis — depends on the activity of the transcription factor SOX9.

    • Kim Baumann
    Research Highlight
  • Somite formation, crucial for organization of the segmental pattern of vertebrate embryos, depends on the oscillatory expression of segmentation clock genes. Novel in vitro models of somitogenesis have provided insights into the spatiotemporal dynamics of gene expression, signalling and metabolic gradients that enable somite formation and patterning.

    • Yuchuan Miao
    • Olivier Pourquié
    Review Article
  • Gene regulation in animals depends chiefly on enhancers, yet the underlying mechanisms are poorly understood. This Review discusses enhancer–promoter interactions and transcription activation, focusing on how enhancer–promoter selectivity is achieved and on recent technical advances that may provide new insights into transcription activation.

    • Jin H. Yang
    • Anders S. Hansen
    Review Article
  • The prevailing challenge in live-cell fluorescence microscopy is capturing intra-cellular dynamics while preserving cell viability. Alongside developments of microscopy hardware, computational methods — especially those based on machine learning — are powerful tools to improve the signal-to-noise ratio, spatial resolution, temporal resolution and multi-colour capacity of live-cell imaging.

    • Hari Shroff
    • Ilaria Testa
    • Suliana Manley
    Review Article
  • Cilia are microtubule-based cell projections that provide a unique environment with precise protein, lipid and second messenger concentrations, thereby creating specialized signalling hubs. This Review discusses recent multidisciplinary, mechanistic insights into cilia-based signalling pathways during development and homeostasis.

    • Keren I. Hilgendorf
    • Benjamin R. Myers
    • Jeremy F. Reiter
    Review Article