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  • Chiara Zurzolo brings to attention the pioneering work that established virus-infected cells as a model to study cell polarity.

    • Chiara Zurzolo
    Journal Club
  • Cheng, Mittnenzweig et al. demonstrate the cellular role of the major DNA demethylation machinery, ten-eleven translocation (TET) dioxygenases, in early mammalian development.

    • Paulina Strzyz
    Research Highlight
  • Actin cytoskeleton underlies key cellular processes, such as membrane dynamics and cell migration. Despite years of research, how cells regulate actin filament assembly and disassembly to establish dynamic actin structures that fulfil these functions remains an exciting area of study.

    • Pekka Lappalainen
    • Tommi Kotila
    • Guillaume Romet-Lemonne
    Review Article
  • The generation of membrane curvature is essential for the formation of membrane tubules, sheets and vesicles, and hence, underlies membrane trafficking events. Various protein-based mechanisms function in membrane bending, and these appear to be organized in time and space by protein coats, including clathrin, caveolar coat complex, and COPI and COPII coats.

    • Michael M. Kozlov
    • Justin W. Taraska
    Review Article
  • Rashmi Sasidharan highlights the work by Musgrave et al. (1972) demonstrating that ethylene drives shoot elongation in plants submerged in water, allowing the plant to outgrow the floodwaters.

    • Rashmi Sasidharan
    Journal Club
  • Kirova et al. demonstrate that reactive oxygen species signals are integrated into cell cycle control through a direct interaction with cyclin-dependent kinase 2.

    • Lisa Heinke
    Research Highlight
  • Stem cell function declines during ageing, resulting in the loss of tissue integrity and health deterioration. Ageing is associated with defects in the maintenance of stem cell quiescence and cell differentiation ability, clonal expansion and infiltration of immune cells in the niche. This Review discusses the mechanisms underlying ageing in stem cells and their niches, and potential rejuvenation strategies.

    • Anne Brunet
    • Margaret A. Goodell
    • Thomas A. Rando
    Review Article
  • Marta Shahbazi recounts the work by Lewis and Rossant (1982) that pioneered research on size regulation in mammalian embryos.

    • Marta N. Shahbazi
    Journal Club
  • Luciano Marcon discusses the revolutionary work by Alan Turing proposing that embryogenesis could be entirely a self-organizing process.

    • Luciano Marcon
    Journal Club
  • Sladitschek-Martens show that reduced activity of key cellular mechanosensors, transcription co-activators YAP/TAZ, is an important driver of ageing of stromal and contractile cells, leading to cell senescence.

    • Paulina Strzyz
    Research Highlight
  • Mitochondrial respiratory function needs to adapt to the energetic demands of the cell. These adaptive responses encompass transcriptional, translational and post-translational mechanisms that together enable regulation of respiratory chain assembly and mitochondrial membrane remodelling to fine-tune energy generation in accordance with intracellular and extracellular cues.

    • Christopher F. Bennett
    • Pedro Latorre-Muro
    • Pere Puigserver
    Review Article
  • Elvan Böke recounts the pioneering work of Arthur T. Hertig on the ultrastructure of human oocytes.

    • Elvan Böke
    Journal Club
  • Zhang et al. show that in fungal and plant cells CO2 sensing involves liquid–liquid phase separation of PP2C phosphatases.

    • Lisa Heinke
    Research Highlight
  • Alternative cleavage and polyadenylation (APA) generates mRNA isoforms with alternative 3′ untranslated regions; these isoforms modulate protein abundance and functionality, including through subcellular localization of mRNA and translation. APA is modulated by signalling pathways that control co-transcriptional and post-transcriptional processes, and its dysregulation affects cell responses to environmental changes.

    • Sibylle Mitschka
    • Christine Mayr
    Review Article
  • Hiroshide Saito discusses two seminal papers that provided foundational evidence for the hypothesis that RNA with both genetic information and catalytic activity had an essential role in the origin of life.

    • Hirohide Saito
    Journal Club
  • Kempson and colleagues suggest that existing imaging assays do not quantitatively represent double-strand DNA breaks, and urge the development of more accurate assays.

    • Jake Atkinson
    • Eva Bezak
    • Ivan Kempson
    Comment
  • Olivia Rissland recounts the findings of a paper that was seminal to our understanding of mRNA decay.

    • Olivia S. Rissland
    Journal Club
  • Reactive oxygen species (ROS) signalling is crucial in plant responses to abiotic and biotic stresses. This Review discusses our current understanding of ROS regulation and sensing in plants, key regulatory hubs that connect ROS signalling with other stress-response pathways and how ROS signalling could be harnessed to increase plant resilience to environmental stress.

    • Ron Mittler
    • Sara I. Zandalinas
    • Frank Van Breusegem
    Review Article