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  • Organelles are normally transmitted to progeny exclusively through the maternal germ line. Chung et al. now describe genetic and environmental factors that increase the inheritance of plastids through pollen.

    • Lisa Heinke
    Research Highlight
  • The increased expression of certain human endogenous retroviruses induces the cGAS–STING pathway and drives cell senescence and ageing.

    • Eytan Zlotorynski
    Research Highlight
  • Yonatan Stelzer highlights a landmark work from the lab of Howard Cedar that addresses how genome-wide DNA methylation patterns are established and instructed by the DNA sequence.

    • Yonatan Stelzer
    Journal Club
  • Metabolites are generally viewed as intermediates or products of metabolism. However, many metabolites are also signalling molecules that regulate metabolic reactions and other processes in development, homeostasis and disease. As such, metabolites can confer adaptive responses to environmental changes.

    • Steven Andrew Baker
    • Jared Rutter
    Review Article
  • Early zebrafish embryos increase the size and complexity of their nuclear pore complexes, enabling efficient nuclear import of maternal transcription factors, which induces zygotic genome activation.

    • Eytan Zlotorynski
    Research Highlight
  • The inability of the mammalian central nervous system to functionally regenerate after injury is largely attributable to the limited capacity of injured neurons to regrow axons. In the spinal cord, recent work on the mechanisms restricting axon regrowth suggests new therapeutic avenues to promote functional recovery after damage.

    • Binhai Zheng
    • Mark H. Tuszynski
    Review Article
  • This Consensus Statement addresses the definition, nomenclature and classification of long non-coding RNAs, and provides a shared viewpoint on their features and functions. The authors also discuss research challenges and provide recommendations to advance our understanding of long non-coding RNAs.

    • John S. Mattick
    • Paulo P. Amaral
    • Mian Wu
    Consensus Statement
  • The proteins apoptosis regulator BAX (BAX), BCL-2 homologous antagonist/killer (BAK) and BCL-2-related ovarian killer protein (BOK), gasdermins and mixed lineage kinase domain-like protein (MLKL) are key executioners of regulated cell death by forming pores across the plasma or mitochondrial membrane. This Review discusses structural rearrangements during activation and oligomerization of these proteins and highlights commonalities and differences of pore formation mechanisms.

    • Peter Vandenabeele
    • Geert Bultynck
    • Savvas N. Savvides
    Review Article
  • Zhang et al. report that angiogenesis in the chick embryo is supported by migrasomes — recently described organelles produced by migrating cells.

    • Paulina Strzyz
    Research Highlight
  • Cockburn et al. report that cells exiting the epidermal stem cell layer show a gradual progression of transcriptional changes during differentiation and retain the ability to divide once differentiation-committed.

    • Lisa Heinke
    Research Highlight
  • The oncoprotein MYC undergoes multimerization to limit transcription–replication conflicts, thereby reducing the formation of DNA double-strand breaks in cancer cells.

    • Eytan Zlotorynski
    Research Highlight
  • Membraneless organelles (MLOs) contribute to intracellular compartmentalization and to various cellular processes. This Review provides a guide to MLOs involved in gene regulation in eukaryotes, discussing their assembly, structure, roles in transcription, RNA processing and translation — particularly in stress conditions — and their disease relevance.

    • Tetsuro Hirose
    • Kensuke Ninomiya
    • Tomohiro Yamazaki
    Review Article
  • In this World View, Felicity Davis discusses how efforts surrounding diversity, equity and inclusion (DEI) often serve to tick a mandatory box, rather than delivering a meaningful change in the DEI space.

    • Felicity M. Davis
    World View
  • Bera et al. demonstrate that increased viscosity of the surrounding fluid promotes cell migration, supporting tumour cell dissemination and tissue colonization in vivo.

    • Paulina Strzyz
    Research Highlight
  • The genome contains various non-coding regulatory elements, including silencers of gene expression. Recent progress in the identification and characterization of silencers has considerably deepened our understanding of their function, and has shed light on the potential relevance of targeting silencers in therapy for hereditary diseases.

    • Baoxu Pang
    • Jan H. van Weerd
    • Michael P. Snyder
    Review Article
  • Malka et al. uncover thousands of 5′ uncapped and polyadenylated transcripts (5′ UPTs) and describe their biogenesis through the alternative polyadenylation pathway. 5′ UPTs contribute to the proteome as non-canonical peptides with likely diverse biological functions.

    • Lisa Heinke
    Research Highlight