• Condensates universe

    We present a selection of articles that highlights recent progress in understanding the functions of biomolecular condensates in cells, and how their composition and formation are regulated.

  • ECR

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    • Liver regeneration involves multiple cell types, including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. Recent studies have elucidated the interactions between these cells during regeneration as well as the mechanisms that regulate cell proliferation and fibrosis remodelling, and have uncovered macrophages as key players. Such findings can help design novel therapeutic approaches.

      • Lara Campana
      • Hannah Esser
      • Stuart Forbes
      Review Article
    • The canonical function of endocytosis is molecule internalization. Beyond this role, endocytic trafficking has emerged as a process central to the spatiotemporal regulation of cell signalling. Endocytic trafficking thus controls many cellular processes and tissue-wide properties, including cell migration and polarity, and its deregulation has been implicated in pathologies, particularly cancer.

      • Sara Sigismund
      • Letizia Lanzetti
      • Pier Paolo Di Fiore
      Review Article
    • Cells can sense various signals, including chemical, mechanical, geometric and electrical signals, and migrate towards or away from them. Such directed cell migration involves signal generation, sensing and transduction that eventually lead to polarized force generation. Deciphering the mechanisms underlying these processes is crucial to understanding cell migration in vivo.

      • Shuvasree SenGupta
      • Carole A. Parent
      • James E. Bear
      Review Article
    • Recent technological breakthroughs in mapping and visualizing chromatin contacts have considerably improved our understanding of 3D genome organization and function. This Review discusses the features, strengths and limitations of various methods of genome organization analysis, including sequencing-based techniques, microscopy-based techniques and computational and modelling approaches.

      • Ivana Jerkovic´
      • Giacomo Cavalli
      Review Article
  • Nuclear condensates of m6A-methylated mRNAs with their ‘reader’ YTHDC1 prevent the degradation of acute myeloid leukaemia-promoting mRNAs by the exosome.

    • Eytan Zlotorynski
    Research Highlight
  • Elif Nur Firat-Karalar brings to our attention the early works by Sergei Sorokin that paved the way for research into the biogenesis and function of primary cilia.

    • Elif Nur Firat-Karalar
    Journal Club
  • The transcription factor p53 boosts the expression of a distinct subset of its target genes by enhancing their association with nuclear speckles.

    • Eytan Zlotorynski
    Research Highlight
20th Anniversary

20th Anniversary

NRMCB is 20! To mark this anniversary, we selected Review articles in 10 core areas of the journal. The Reviews are presented in pairs, an older and a more recent one, alongside 10 commissioned Journal Clubs — together the articles showcase developments and key discoveries in each research field.

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