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    • Actin cytoskeleton underlies key cellular processes, such as membrane dynamics and cell migration. Despite years of research, how cells regulate actin filament assembly and disassembly to establish dynamic actin structures that fulfil these functions remains an exciting area of study.

      • Pekka Lappalainen
      • Tommi Kotila
      • Guillaume Romet-Lemonne
      Review Article
    • The generation of membrane curvature is essential for the formation of membrane tubules, sheets and vesicles, and hence, underlies membrane trafficking events. Various protein-based mechanisms function in membrane bending, and these appear to be organized in time and space by protein coats, including clathrin, caveolar coat complex, and COPI and COPII coats.

      • Michael M. Kozlov
      • Justin W. Taraska
      Review Article
    • Stem cell function declines during ageing, resulting in the loss of tissue integrity and health deterioration. Ageing is associated with defects in the maintenance of stem cell quiescence and cell differentiation ability, clonal expansion and infiltration of immune cells in the niche. This Review discusses the mechanisms underlying ageing in stem cells and their niches, and potential rejuvenation strategies.

      • Anne Brunet
      • Margaret A. Goodell
      • Thomas A. Rando
      Review Article
    • Mitochondrial respiratory function needs to adapt to the energetic demands of the cell. These adaptive responses encompass transcriptional, translational and post-translational mechanisms that together enable regulation of respiratory chain assembly and mitochondrial membrane remodelling to fine-tune energy generation in accordance with intracellular and extracellular cues.

      • Christopher F. Bennett
      • Pedro Latorre-Muro
      • Pere Puigserver
      Review Article
    • Alternative cleavage and polyadenylation (APA) generates mRNA isoforms with alternative 3′ untranslated regions; these isoforms modulate protein abundance and functionality, including through subcellular localization of mRNA and translation. APA is modulated by signalling pathways that control co-transcriptional and post-transcriptional processes, and its dysregulation affects cell responses to environmental changes.

      • Sibylle Mitschka
      • Christine Mayr
      Review Article
  • Chiara Zurzolo brings to attention the pioneering work that established virus-infected cells as a model to study cell polarity.

    • Chiara Zurzolo
    Journal Club
  • Cheng, Mittnenzweig et al. demonstrate the cellular role of the major DNA demethylation machinery, ten-eleven translocation (TET) dioxygenases, in early mammalian development.

    • Paulina Strzyz
    Research Highlight
  • Rashmi Sasidharan highlights the work by Musgrave et al. (1972) demonstrating that ethylene drives shoot elongation in plants submerged in water, allowing the plant to outgrow the floodwaters.

    • Rashmi Sasidharan
    Journal Club
  • Kirova et al. demonstrate that reactive oxygen species signals are integrated into cell cycle control through a direct interaction with cyclin-dependent kinase 2.

    • Lisa Heinke
    Research Highlight
  • Marta Shahbazi recounts the work by Lewis and Rossant (1982) that pioneered research on size regulation in mammalian embryos.

    • Marta N. Shahbazi
    Journal Club
The sea with lipid rafts

Lipids and membranes

This article series brings together Reviews that focus on key advances in understanding membrane biology as well as the regulation and functions of their lipid components, including their roles as bioactive molecules and their interplay with metabolism.
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