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  • Condensates universe

    We present a selection of articles that highlights recent progress in understanding the functions of biomolecular condensates in cells, and how their composition and formation are regulated.

  • ECR

    Nature Reviews Molecular Cell Biology is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is appropriately recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

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    • Satellite cells are skeletal muscle stem cells that are largely quiescent. They are activated upon muscle damage and differentiate into muscle cells or return to quiescence. These processes are controlled by cell-intrinsic mechanisms and by signals from the niche, and are deregulated in ageing, leading to impaired muscle regeneration.

      • Pedro Sousa-Victor
      • Laura García-Prat
      • Pura Muñoz-Cánoves
      Review Article
    • Mitochondrial respiration relies on five enzymatic complexes that couple electron transport with proton pumping, leading to ATP synthesis. Recent studies have shed new light on the organization, assembly and mechanisms of the respiratory complexes, including the formation of their larger assemblies — respiratory supercomplexes — and their roles in physiology.

      • Irene Vercellino
      • Leonid A. Sazanov
      Review Article
    • Entry of SARS-CoV-2 into host cells is mediated by the interaction between the viral spike protein and its receptor angiotensin-converting enzyme 2, followed by virus–cell membrane fusion. Worldwide research efforts have provided a detailed understanding of this process at the structural and cellular levels, enabling successful vaccine development for a rapid response to the COVID-19 pandemic.

      • Cody B. Jackson
      • Michael Farzan
      • Hyeryun Choe
      Review Article
    • Recent studies have revolutionized our understanding of the interplay between mRNA poly(A) tails and the processes of translation and mRNA decay in the cytoplasm. Poly(A) tails interact with dedicated RNA-binding proteins and deadenylases, which together determine the impact of poly(A) tails on gene expression.

      • Lori A. Passmore
      • Jeff Coller
      Review Article
    • Integral membrane proteins make up around one quarter of the human proteome and are highly diverse in topology, biophysical features, structure and function. Their biogenesis involves multiple pathways for membrane targeting, insertion into the lipid bilayer, folding and assembly with other subunits. Recent biochemical and structural analyses have provided new insights into these mechanisms.

      • Ramanujan S. Hegde
      • Robert J. Keenan
      Review Article
  • The 2021 Nobel Prize in Physiology or Medicine goes to David Julius and Ardem Patapoutian for their work on molecular basis of somatosensation.

    • Paulina Strzyz
    Research Highlight
  • Xie et al. show that the hair shaft regulates the size of the hair follicle stem cell niche and consequently its maintenance.

    • Paulina Strzyz
    Research Highlight
  • tiRNA-containing extracellular vesicles produced by osteoblasts in the bone marrow are taken up by granulocyte–monocyte progenitors, which promotes their proliferation, increasing host immunity.

    • Kim Baumann
    Research Highlight
  • An amino acid substitution found in a ribosomal protein in archaea can increase translation fidelity and lifespan in metazoans.

    • Eytan Zlotorynski
    Research Highlight
  • Xu et al. report engineering a compact version of Cas that can be useful for a broad range of genome engineering applications in mammalian cells.

    • Paulina Strzyz
    Research Highlight
  • Tau oligomers bind to m6A-modified RNA transcripts in the cytoplasm via the linker RNA-binding protein HNRNPA2B1; such complexes are found in individuals with Alzheimer disease and are part of a stress response that represses translation.

    • Kim Baumann
    Research Highlight
20th Anniversary

20th Anniversary

NRMCB is 20! To mark this anniversary, we selected Review articles in 10 core areas of the journal. The Reviews are presented in pairs, an older and a more recent one, alongside 10 commissioned Journal Clubs — together the articles showcase developments and key discoveries in each research field.
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