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    Are you an early-career researcher who is working with a cool tool or method? Would you like others to learn about it? Let us know! We are introducing Tools of the Trade articles to showcase the role of ECRs in driving technological advancements in molecular cell biology. Email us at nrm@nature.com the method/tool you'd like to write about and why it's important.

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    • The prevailing challenge in live-cell fluorescence microscopy is capturing intra-cellular dynamics while preserving cell viability. Alongside developments of microscopy hardware, computational methods — especially those based on machine learning — are powerful tools to improve the signal-to-noise ratio, spatial resolution, temporal resolution and multi-colour capacity of live-cell imaging.

      • Hari Shroff
      • Ilaria Testa
      • Suliana Manley
      Review Article
    • Cilia are microtubule-based cell projections that provide a unique environment with precise protein, lipid and second messenger concentrations, thereby creating specialized signalling hubs. This Review discusses recent multidisciplinary, mechanistic insights into cilia-based signalling pathways during development and homeostasis.

      • Keren I. Hilgendorf
      • Benjamin R. Myers
      • Jeremy F. Reiter
      Review Article
    • Ferroptosis is a non-apoptotic, iron-dependent cell death mechanism driven by plasma membrane lipid peroxidation and subsequent plasma membrane rupture. Various cellular compartments and organelles contribute to regulating susceptibility to ferroptosis. This regulation involves a plethora of mechanisms centred on iron metabolism and storage, lipid metabolism, and redox balance.

      • Scott J. Dixon
      • James A. Olzmann
      Review Article
    • Protein S-acylation is involved in many pathophysiological processes. Here, Mesquita et al. discuss the structure, function and regulation of S-acylation and deacylation enzymes and describe how this post-transcriptional modification precisely controls protein–cell membrane interactions. Potential therapeutic applications of S-acylation are also highlighted.

      • Francisco S. Mesquita
      • Laurence Abrami
      • F. Gisou van der Goot
      Review Article
    • L. Villiger, J. Joung et al. review CRISPR applications for programmable editing of the genome, epigenome and transcriptome. They discuss how CRISPR–Cas systems can be optimized to further improve editing specificity and efficiency and highlight a multitude of applications in basic biological research and for changing clinical practice.

      • Lukas Villiger
      • Julia Joung
      • Jonathan S. Gootenberg
      Review Article
  • Joana Vidigal reminds us of the first paper to report an endogenous role of the nucleolytic activity of the mammalian RNAi protein argonaute-2.

    • Joana A. Vidigal
    Journal Club
  • In this Tools of the Trade article, Khalid Ibrahim (Radenovic and Lashuel labs) describes a tool for the artificial intelligence (AI)-driven detection of cellular aggregates that bypasses the need for fluorescent labelling.

    • Khalid A. Ibrahim
    Tools of the Trade
  • Rapid reactivation of gene expression following mitosis-induced silencing is facilitated by a network of redundantly acting nuclear receptors that function as mitotic bookmarks.

    • Lisa Heinke
    Research Highlight
The sea with lipid rafts

Lipids and membranes

This article series brings together Reviews that focus on key advances in understanding membrane biology as well as the regulation and functions of their lipid components, including their roles as bioactive molecules and their interplay with metabolism.
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