colourful shapes on a blue background representing mTOR complexes

Sensing and signalling by mTORC1

Structural and functional features of nutrient-mediated mTORC1 regulation


  • Voices of the new generation

    Are you an early-career researcher/new principal investigator and are interested in sharing your experiences with others? NRMCB has opened a space to do just that! If you like the idea, please get in touch with us at with suggestions for potential content for this section.

  • Spanners with embryos

    Share your Tools of the Trade

    Are you an early-career researcher who is working with a cool tool or method? Would you like others to learn about it? Let us know! We are introducing Tools of the Trade articles to showcase the role of ECRs in driving technological advancements in molecular cell biology. Email us at the method/tool you'd like to write about and why it's important.

  • ECR initiative

    Nature Reviews Molecular Cell Biology is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is appropriately recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

  • DNA–protein interactions

    Check out our new structure–function article series, in which we collate Reviews that present important structural findings and illuminate their mechanistic and functional significance.


  • In this Tools of the Trade article, Manuela Richter (Dumont lab) describes a method to probe mechanisms of cytoskeletal network re-organization that uses a targeted laser to both trigger network remodelling and track network dynamics.

    • Manuela Richter
    Tools of the Trade
  • In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis in mice (surgical connection between circulatory systems for an extended period), followed by detachment, can shed light on potential mechanisms that reverse mammalian ageing.

    • Bohan Zhang
    Tools of the Trade
  • Phosphorylation of the mitochondrial DNA (mtDNA) maintenance factor TFAM during spermatogenesis prevents its import into mitochondria, resulting in elimination of paternal mtDNA and leading to maternal inheritance.

    • Eytan Zlotorynski
    Research Highlight
The sea with lipid rafts

Lipids and membranes

This article series brings together Reviews that focus on key advances in understanding membrane biology as well as the regulation and functions of their lipid components, including their roles as bioactive molecules and their interplay with metabolism.


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