Vicky Summersby

Regulation of apoptosis by BCL-2 proteins

Review by Singh, Letai & Sarosiek            

Latest Reviews

  • Review Article |

    The haematopoietic stem cell (HSC) niche in the bone marrow ensures haematopoiesis by regulating the function of HSCs and progenitor cells. An improved understanding of this regulation in homeostasis, ageing and cancer should aid the development of therapies to rejuvenate aged HSCs or niches and treat malignancies.

    • Sandra Pinho
    •  & Paul S. Frenette
  • Review Article |

    By opposing protein ubiquitylation, deubiquitylating enzymes (DUBs) regulate various cellular processes, including protein degradation, the DNA damage response, cell signalling and autophagy. Many DUBs show high specificity for ubiquitin chain architecture and/or the protein substrate that they recognize, and have emerged as exciting therapeutic targets within the field of proteostasis.

    • Michael J. Clague
    • , Sylvie Urbé
    •  & David Komander
  • Review Article |

    Misfolded proteins have a high propensity to form potentially toxic aggregates. Cells employ a complex network of processes, involving chaperones and proteolytic machineries that ensure proper protein folding and remodel or degrade misfolded species and aggregates. This proteostasis network declines with age, which can be linked to human degenerative diseases.

    • Mark S. Hipp
    • , Prasad Kasturi
    •  & F. Ulrich Hartl
  • Review Article |

    Spatial proteomics improves our understanding of protein function by revealing the subcellular localizations of proteins and their movement between compartments. This Review discusses spatial proteomics approaches, their successful application in cell biology and ways to improve integration of spatial proteomics data.

    • Emma Lundberg
    •  & Georg H. H. Borner
  • Review Article |

    BCL-2 family proteins are the mediators of apoptotic cell death. The balance between pro-apoptotic and pro-survival BCL-2 family members is differently regulated in various physiological contexts to modulate cellular apoptotic susceptibility. Perturbation of this balance causes excessive or insufficient cell death, leading to diseases such as neurodegeneration and cancer.

    • Rumani Singh
    • , Anthony Letai
    •  & Kristopher Sarosiek
  • Review Article |

    Circadian rhythms align organismal functions with phases of rest and activity. Accordingly, circadian oscillations occur in many physiological processes, including various metabolic functions. In turn, metabolic cues are emerging as regulators of the circadian clock. This crosstalk between metabolism and circadian rhythms has important implications for human health.

    • Hans Reinke
    •  & Gad Asher

News & Comment

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    • Paulina Strzyz
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    Lipin 1 and ARF1 control SREBP trafficking, processing and activity to regulate lipid synthesis in response to mechanical cues from the extracellular matrix.

    • Grant Otto
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    Cells can efficiently invade the tissue in the absence of metalloproteinases by physically breaching the basement membrane.

    • Paulina Strzyz
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    Cells in telomere crisis undergo cell death through autophagy, which is triggered by chromosome breakage and transduced by the cGAS–STING pathway.

    • Eytan Zlotorynski
  • Research Highlight |

    Palmitoylation-driven partitioning of importin-α at the plasma membrane contributes to intracellular scaling.

    • Paulina Strzyz

Series

Translation and protein quality control

Vicky Summersby

Translation and protein quality control

A series of articles from Nature Reviews Molecular Cell Biology on protein synthesis and translation-associated protein quality control, and their deregulation in human disease.

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