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Mathematical models have been used to guide strategies for COVID-19 vaccine distribution. But with the emergence of new SARS-CoV-2 variants and waning immunity, how should vaccine distribution be prioritized?
Intestinal ILC3s produce the epidermal growth factor family mediator HB-EGF, which protects the intestinal barrier against TNF-induced epithelial cell death.
T cells need magnesium to function efficiently. They sense it via the cell surface integrin LFA-1, which triggers outside-in signalling to augment T cell effector functions against infection or cancers.
A preprint by Ukita et al. describes a role for CXCL13-producing T helper cells in promoting the formation of tertiary lymphoid structures in ovarian cancer that are associated with improved clinical outcome.
A longitudinal study of CAR T cells from patients successfully treated for chronic lymphocytic leukaemia in 2010 provides fascinating insights into CAR T cell features that allow for long-term control of disease.
The transcription factor TCF1 is essential for early T cell development, and recent advances have uncovered context-dependent functions in mature T cells. This review summarizes key findings on TCF1 across the field of T cell immunity and explores their translational potential.
Vignali and colleagues discuss the pleiotropic roles of interferon-γ (IFNγ) in the tumour microenvironment; on the one hand, it acts as a ‘teammate’ to promote antitumour immune responses and, on the other hand, it acts as an ‘opponent’ promoting tumour growth and suppressing immune responses.
Neutrophils are much more than just primary responders in infection. They influence tumour development and growth in many positive and negative ways. A growing appreciation of their diversity and plasticity is revealing their complex contributions to cancer depending on time, place and disease context.
Phase separation has emerged as a new biophysical principle for organizing biomolecules into large clusters with fluidic properties. Here, Su and colleagues summarize what we currently know about phase separation in immune cells and look to the future of this field in understanding the regulation of immune signalling.
