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Volume 22 Issue 11, November 2022

Homing in on the gut, inspired by the Review on p674.

Cover design: Simon Bradbrook


  • Wildfires are increasing globally, with several recent catastrophic wildfires linked to climate change. Here, we consider the negative impact of the toxic contaminants arising from these fires on the immune system, with a focus on how wildfire pollution can exacerbate inflammatory diseases.

    • Cezmi A. Akdis
    • Kari C. Nadeau


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Research Highlights

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  • This Review from Tansey and colleagues explores how an ageing immune system, host genetics and exposure to various environmental stressors combine to promote the development of Parkinson disease.

    • Malú Gámez Tansey
    • Rebecca L. Wallings
    • Valerie Joers


    Review Article
  • The authors of this Review discuss the current evidence suggesting that pathological immune activation contributes to irritable bowel syndrome (IBS). They explain how immune mediators can contribute to pain signalling and abdominal pain, and highlight the potential for targeting immune pathways in IBS.

    • Javier Aguilera-Lizarraga
    • Hind Hussein
    • Guy E. Boeckxstaens
    Review Article
  • This Review discusses the immunomodulatory properties of phosphoinositide 3-kinase-γ (PI3Kγ) in health and in the context of various diseases, ranging from cardiovascular disease to auto-immunity and cancer, and discusses the therapeutic potential of PI3Kγ inhibitors, which have entered clinical trials for cancer.

    • Stephen M. Lanahan
    • Matthias P. Wymann
    • Carrie L. Lucas
    Review Article
  • Type 2 innate lymphoid cells (ILC2s) have diverse phenotypes across different tissues and disease states. Recent insights into ILC2 biology raise new possibilities for the improved treatment of cancer and of metabolic, infectious and chronic inflammatory diseases.

    • Hergen Spits
    • Jenny Mjösberg
    Review Article
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