Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
In this Comment article, Sofonias Tessema and John Nkengasong provide an overview of the current state of the COVID-19 pandemic in Africa and the challenges posed by the triple burden of emerging, endemic and non-communicable diseases.
A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.
This study reports serum metabolome profiling of children naturally infected with Plasmodium falciparum in Burkina Faso, West Africa, revealing major changes in endogenous steroid levels with effects on adaptive immunity.
A new study in Cell provides a cellular atlas of the oral mucosa, revealing complex stromal–immune cell interactions that support inflammatory responsiveness and neutrophil recruitment.
This Progress article summarizes our current understanding of the immune mechanisms of protection induced by the available COVID-19 vaccines. The authors compare vaccine-induced antibody responses following one or two doses of different vaccines and consider the relative importance of neutralizing antibodies for vaccine-mediated protection against SARS-CoV-2.
This Review from Gabrilovich and colleagues discusses our current understanding of the development and functions of myeloid-derived suppressor cells (MDSCs). Recent work has identified unique metabolic properties and gene expression patterns in MDSCs that could help in the development of new therapies for cancer and autoimmunity.
Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering multiple immune functions. Here, the authors describe the recent discovery of new RHO GTPase partners and genetic mutations in RHO GTPase signalling hubs that may provide novel therapeutic opportunities.
Intestinal IgA is important for regulating the commensal microbiota and for preventing harmful pathogens from colonizing the intestine. In this Review, Huus, Petersen and Finlay consider the host, bacterial and environmental factors that shape IgA–microbiota interactions in the intestine.
In this Review, Kipnis and colleagues explain how signals from the immune system can shape host behavioural responses, even in the absence of infection or disease. In particular, the authors focus on the cytokine pathways that modulate behavioural responses and consider the evolutionary basis of these neuroimmune interactions.
