Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 21 Issue 12, December 2021

Vaccination for all, inspired by the Perspective on p815.

Cover design: Simon Bradbrook

Volume 21 Issue 12

Comment

  • Here, John Kelton and colleagues provide an overview of vaccine-induced immune thrombotic thrombocytopenia (VITT), a very rare complication that has been observed following vaccination with adenoviral vector-based COVID-19 vaccines.

    • John Greenhow Kelton
    • Donald Mitchell Arnold
    • Ishac Nazy

    Collection:

    Comment

    Advertisement

  • Black In Immuno harnesses social media and digital platforms to connect Black immunologists with one another and with the rest of the scientific ecosystem. We invite you to join us, to connect with and amplify Black immunologists, and to contribute to creating a more inclusive and innovative biomedical community.

    • Joel Babdor
    • Amy C. Fan
    • Elaine Kouame
    Comment
Top of page ⤴

Research Highlights

Top of page ⤴

Progress

  • Individuals with asymptomatic COVID-19 can transmit the virus and may be at risk of long-term disease. In this Progress article, Boyton and Altman present current insights into immune responses in asymptomatic SARS-CoV-2 infection and discuss the relevance of asymptomatic disease for public health strategies.

    • Rosemary J. Boyton
    • Daniel M. Altmann

    Collection:

    Progress
Top of page ⤴

Reviews

  • Successful adoptive cell therapy for cancer depends on the expansion and persistence of tumour-specific T cells with stem-like memory or precursor characteristics. Here, the authors describe approaches to generate these cells by in vitro culture methods, by modulating transcriptional, metabolic and/or epigenetic programming, and by fine-tuning antigen receptor signalling.

    • Jack D. Chan
    • Junyun Lai
    • Phillip K. Darcy
    Review Article
  • Immunotherapeutic approaches to cancer can be affected by metabolic restrictions that limit the potency of anticancer T cell responses. In this Review, DePeaux and Delgoffe discuss the metabolic features of the tumour microenvironment that limit anticancer immune responses, as well as emerging therapeutic approaches to target these.

    • Kristin DePeaux
    • Greg M. Delgoffe
    Review Article
  • Here, Harald Prüss discusses how autoantibodies can contribute to neurological diseases. The identification of specific autoantibodies to neuronal and glial targets has increased our understanding of autoimmunity in the central nervous system and led to the reclassification of some diseases previously thought to result from infection or ‘idiopathic’ causes.

    • Harald Prüss

    Series:

    Review Article
Top of page ⤴

Perspectives

  • Emerging diseases that affect humans often arise due to the crossover of infectious agents from animal reservoirs. In this Perspective, George Warimwe and colleagues discuss the concept of ‘One Health vaccinology’, an approach that aims to use key lessons from human and veterinary immunology to develop more effective vaccination strategies for emerging infectious diseases.

    • George M. Warimwe
    • Michael J. Francis
    • Bryan Charleston

    Collection:

    Perspective
  • This Perspective chronicles the journey to the elimination of transmission of wild poliovirus in Africa, with a critical discussion of the global, continental, national and community actions that were required and the lessons learnt along the way.

    • Abdulaziz Mohammed
    • Oyewale Tomori
    • John N. Nkengasong
    Perspective
Top of page ⤴

Correspondence

Top of page ⤴

Search

Quick links