Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 21 Issue 11, November 2021

COVER: SARS-CoV-2 ignites the inflammasome, inspired by the Progress on p694.

Cover design: Simon Bradbrook


Top of page ⤴

Research Highlights

Top of page ⤴


  • This Progress article brings us up to date on the role of inflammasomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19, describing how they may be activated during infection and contribute to the overexuberant inflammatory response in severe disease, and the efforts being taken to target them therapeutically.

    • Setu M. Vora
    • Judy Lieberman
    • Hao Wu


Top of page ⤴


  • Fibroblasts are not just crucial structural cells; they exist as multiple functionally diverse populations, defined by their location and context, and regulate tissue immunity. Here, the authors review the immunological properties of fibroblasts, comprising both pro-inflammatory and immunosuppressive activities, in different tissues and disease states.

    • Sarah Davidson
    • Mark Coles
    • Christopher D. Buckley
    Review Article
  • This Review examines the metabolic adaptations that occur in CD8+ T cells in the settings of infection and cancer. The authors discuss the key metabolic features of activated, memory, tissue-resident and dysfunctional CD8+ T cell populations and also consider how overall host metabolism can affect the CD8+ T cell response.

    • Miguel Reina-Campos
    • Nicole E. Scharping
    • Ananda W. Goldrath
    Review Article
Top of page ⤴

Amendments & Corrections

Top of page ⤴


Quick links