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A systematic analysis of the ageing immune system of the mouse revealed the emergence of a novel T cell subset that displays markers of exhaustion. A similar T cell subset was also identified in ageing humans.
A recent study in Science describes that maternal allergen-specific IgE can cross the placenta to sensitize fetal mast cells in mice and predispose to neonatal allergy.
Immunometabolism has a key role in HIV-1 pathogenesis, with the metabolic state of T cells and macrophages determining their susceptibility to infection, the metabolism of immune cells shaping their response to infection and metabolic products driving inflammation during infection.
In this Review, Rolls and colleagues discuss regulation of immune responses by the nervous system. The authors focus on the benefits of neuronal regulation of immunity, the mechanisms involved and the brain areas involved in neuro-immune crosstalk.
This Review covers our current understanding of the roles of IL-9-producing T cells in allergy and cancer. Should these cells be classified as a distinct IL-9-producing T helper cell subset? And can we therapeutically target them for the treatment of chronic allergic diseases and cancer?
In this Perspective, Alon and colleagues discuss how insights into immune cell trafficking during pneumotropic influenza virus infections may inform our understanding of immune cell recruitment to the respiratory tract in patients with coronavirus disease 2019 (COVID-19). Moreover, they examine the emerging knowledge of vascular pathologies beyond the lung caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
