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Volume 20 Issue 9, September 2020

‘Sensing RNA’, inspired by the Review on p537.

Cover design: Simon Bradbrook.

Volume 20 Issue 9

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Research Highlights

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Viewpoint

  • In this Viewpoint, six leading experts consider the ways in which the microbiota can influence immune responses to cancer. Immunotherapies have been revolutionary in the treatment of cancer, but will we one day further increase their efficacy with microbiota-derived drugs?

    • B. Brett Finlay
    • Romina Goldszmid
    • Laurence Zitvogel
    Viewpoint
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Progress

  • In this Progress article, Zeyu Chen and E. John Wherry summarize early reports of the T cell responses observed in patients with COVID-19, emphasizing how different immune response characteristics in different patients may reflect a spectrum of disease phenotypes.

    • Zeyu Chen
    • E. John Wherry

    Collections:

    Progress
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Reviews

  • The RNA-sensing retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are important inducers of type I interferons and other antiviral immune mediators. Here, Jan Rehwinkel and Michaela Gack explain how members of the RLR family are regulated and reflect on the importance of the RLRs in viral infection, autoimmunity and cancer.

    • Jan Rehwinkel
    • Michaela U. Gack
    Review Article

  • Innate lymphoid cell (ILC) subsets with defined phenotypes can adapt to local environmental cues through transdifferentiation. Studies of such plasticity have improved our understanding of the biological roles of ILCs and offer promise for new strategies to treat inflammatory diseases and cancer.

    • Suzanne M. Bal
    • Korneliusz Golebski
    • Hergen Spits
    Review Article

  • Recent single-cell studies have revealed a previously unappreciated heterogeneity among endothelial cells that line the lymphatic sinuses of the lymph nodes. In this Review, the authors describe these various lymphatic endothelial cell types and how they support the trafficking of cells and antigens through lymph nodes.

    • Sirpa Jalkanen
    • Marko Salmi
    Review Article
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Amendments & Corrections

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