Volume 20 Issue 6, June 2020

Volume 20 Issue 6

‘Coronavirus Storm’, inspired by the Review on p363.

Cover design: Simon Bradbrook.

Comment

  • Comment |

    This Comment article from the Precision Immunology Institute at the Icahn School of Medicine (PrIISM), New York, describes their efforts to provide critical reviews of COVID-19 articles posted daily on the preprint servers bioRxiv and medRxiv.

    • Nicolas Vabret
    • , Robert Samstein
    • , Nicolas Fernandez
    • , Miriam Merad
    • , Alessandra Soares Schanoski
    • , Alfonso Rodriguez
    • , Alvaro Moreira
    • , Andrew Chan
    • , Andrew Charap
    • , Andrew Leader
    • , Assaf Magen
    • , Bérengère Salomé
    • , Cansu Cimen Bozkus
    • , Chang Moon
    • , Conor Gruber
    • , Dan Fu Ruan
    • , Daniel Lozano-Ojalvo
    • , Divya Jha
    • , Elliot Meritt
    • , Emma Risson
    • , Erica Dalla
    • , Etienne Humblin
    • , Evan Cody
    • , Francesca Cossarini
    • , Gabrielle Lubitz
    • , Graham Britton
    • , Gustavo Martinez-Delgado
    • , Ivan Reyes Torres
    • , Jaime Mateus-Tique
    • , Jamie Redes
    • , Jessica Tan
    • , Joan Shang
    • , Joel Kim
    • , John Grout
    • , Jonathan Chung
    • , Jovani Catalan
    • , Julia Kodysh
    • , Justine Noel
    • , Katherine Lindblad
    • , Louise Malle
    • , Luisanna Pia
    • , Manasi Agrawal
    • , Maria Casanova-Acebes
    • , Maria Kuksin
    • , Maria Suprun
    • , Mark Aleynick
    • , Mark Roberto
    • , Matthew Brown
    • , Matthew Lin
    • , Matthew Park
    • , Matthew Spindler
    • , Matthias Wilk
    • , Meriem Belabed
    • , Miriam Saffern
    • , Miyo Ota
    • , Monica Centa
    • , Natalie Vaninov
    • , Nicolas Fernandez
    • , Pauline Hamon
    • , Rachel Levantovsky
    • , Samarth Hegde
    • , Steven Chen
    • , Tamar Plitt
    • , Tim O’Donnell
    • , Venu Pothula
    • , Verena Van Der Heide
    • , Zafar Mahmood
    • , Alice Khamporst
    • , Amir Horowitz
    • , Brian Brown
    • , Dirk Homann
    • , Dusan Bogunovic
    • , Emilie Grasset
    • , Ephraim Kenigsberg
    • , Jeremiah Faith
    • , Konstantina Alexandropoulos
    • , Maria Lafaille
    • , Miriam Merad
    • , Nicolas Vabret
    • , Nina Bhardwaj
    • , Peter Heeger
    • , Robert Samstein
    • , Saurabh Mehandru
    •  & Uri Laserson

    Collection:

  • Comment |

    This Comment article from Lambris and colleagues considers the therapeutic potential of targeting the complement system in patients with COVID-19.

    • Antonio M. Risitano
    • , Dimitrios C. Mastellos
    • , Markus Huber-Lang
    • , Despina Yancopoulou
    • , Cecilia Garlanda
    • , Fabio Ciceri
    •  & John D. Lambris

    Collection:

  • Comment |

    Levels of the cytokine IL-17 positively correlate with disease severity in COVID-19. Here, the authors argue that existing anti-IL-17 therapies should be considered for the treatment of severe COVID-19.

    • Omar Pacha
    • , Mary Alice Sallman
    •  & Scott E. Evans

    Collection:

Research Highlights

Progress

Reviews

  • Review Article |

    In the short time since SARS-CoV-2 infections emerged in humans, much has been learned about the immunological processes that underlie the clinical manifestation of COVID-19. Here, the authors provide an overview of the pathophysiology of SARS-CoV-2 infection and discuss potential therapeutic approaches.

    • Matthew Zirui Tay
    • , Chek Meng Poh
    • , Laurent Rénia
    • , Paul A. MacAry
    •  & Lisa F. P. Ng
  • Review Article |

    Here a group of leaders in the field define our current understanding of ‘trained immunity’, which refers to the memory-type responses that occur in the innate immune system. The authors discuss our current understanding of the key epigenetic and metabolic processes involved in trained immunity and consider its relevance in immune-mediated diseases and cancer.

    • Mihai G. Netea
    • , Jorge Domínguez-Andrés
    • , Luis B. Barreiro
    • , Triantafyllos Chavakis
    • , Maziar Divangahi
    • , Elaine Fuchs
    • , Leo A. B. Joosten
    • , Jos W. M. van der Meer
    • , Musa M. Mhlanga
    • , Willem J. M. Mulder
    • , Niels P. Riksen
    • , Andreas Schlitzer
    • , Joachim L. Schultze
    • , Christine Stabell Benn
    • , Joseph C. Sun
    • , Ramnik J. Xavier
    •  & Eicke Latz

    Collection: