Volume 20 Issue 6, June 2020

‘Coronavirus Storm’, inspired by the Review on p363.

Cover design: Simon Bradbrook.

Comment

BCG-induced trained immunity: can it offer protection against COVID-19?

Could the BCG vaccine be used to bridge the gap until a specific COVID-19 vaccine is developed? Luke O’Neill and Mihai Netea discuss the science behind this approach.

Luke A. J. O’Neill
Mihai G. Netea

Collections:

Nature Milestones in Vaccines

COVID-19 Watch
Comment 11 May 2020
Advertisement
Advancing scientific knowledge in times of pandemics

This Comment article from the Precision Immunology Institute at the Icahn School of Medicine (PrIISM), New York, describes their efforts to provide critical reviews of COVID-19 articles posted daily on the preprint servers bioRxiv and medRxiv.

Nicolas Vabret
Robert Samstein
Uri Laserson

Collection:

COVID-19 Watch
Comment 23 Apr 2020
The potential danger of suboptimal antibody responses in COVID-19

Here, Iwasaki and Yang highlight the potential dangers of inducing suboptimal antibody responses to SARS-CoV-2. They stress the need for proper safety evaluation of candidate vaccines for COVID-19.

Akiko Iwasaki
Yexin Yang

Collection:

COVID-19 Watch
Comment 21 Apr 2020
Will helminth co-infection modulate COVID-19 severity in endemic regions?

Helminth co-infections can skew systemic immunity towards type 2 responses. Here, Bradbury and colleagues consider how this may impact the severity of COVID-19 in helminth-endemic regions.

Richard S. Bradbury
David Piedrafita
Siddhartha Mahanty

Collection:

COVID-19 Watch
Comment 01 May 2020
Complement as a target in COVID-19?

This Comment article from Lambris and colleagues considers the therapeutic potential of targeting the complement system in patients with COVID-19.

Antonio M. Risitano
Dimitrios C. Mastellos
John D. Lambris

Collection:

COVID-19 Watch
Comment 23 Apr 2020
COVID-19: a case for inhibiting IL-17?

Levels of the cytokine IL-17 positively correlate with disease severity in COVID-19. Here, the authors argue that existing anti-IL-17 therapies should be considered for the treatment of severe COVID-19.

Omar Pacha
Mary Alice Sallman
Scott E. Evans

Collection:

COVID-19 Watch
Comment 01 May 2020
COVID-19 vaccine design: the Janus face of immune enhancement

Here, Hotez and colleagues highlight the two ‘faces’ of immune enhancement that could impact COVID-19 vaccine design.

Peter J. Hotez
David B. Corry
Maria Elena Bottazzi

Collections:

Nature Milestones in Vaccines

COVID-19 Watch
Comment 28 Apr 2020

Top of page ⤴

Research Highlights

Blocking SIRPα could restore macrophage appetite and mitigate pneumonia

Macrophages show reduced phagocytic capacity after the resolution of an acute inflammation and this may contribute to hospital-acquired pneumonia.

Yvonne Bordon
Research Highlight 01 Jun 2020
Human antibodies can neutralize SARS-CoV-2

Jovani Catalan-Dibene

Collection:

COVID-19 Watch
In Brief 14 Apr 2020
Coronaviruses hijack the complement system

C. Matthias Wilk

Collection:

COVID-19 Watch
In Brief 14 Apr 2020
Hydroxychloroquine: small effects in mild disease

Rachel Levantovsky
Nicolas Vabret

Collection:

COVID-19 Watch
In Brief 14 Apr 2020
Ironing out the details of intestinal repair

A recent study in Science describes a role for dendritic cell-derived hepcidin in iron sequestration in the gut to regulate the microbiota and promote tissue repair.

Kirsty Minton
Research Highlight 14 Apr 2020
HIV hides in platelets

This study shows that platelets can harbour infectious HIV and transfer it to macrophages.

Ursula Hofer
Research Highlight 22 Apr 2020
Will we see protection or reinfection in COVID-19?

Miyo Ota

Collection:

COVID-19 Watch
In Brief 17 Apr 2020
Macrophages: a Trojan horse in COVID-19?

Matthew D. Park

Collection:

COVID-19 Watch
In Brief 17 Apr 2020
A map of SARS-CoV-2 and host cell interactions

Louise Malle

Collection:

COVID-19 Watch
In Brief 17 Apr 2020
Does asthma make COVID-19 worse?

Samarth Hegde

Collection:

COVID-19 Watch
In Brief 28 Apr 2020
Neutralizing antibody response in mild COVID-19

Verena van der Heide

Collection:

COVID-19 Watch
In Brief 28 Apr 2020
Cancer therapy tool informs COVID-19 vaccines

Miriam Saffern

Collection:

COVID-19 Watch
In Brief 28 Apr 2020
Tumours use NETs as physical shields

This study shows that tumour cells can induce neutrophils to undergo NETosis. This shields the tumour cells from attack by cytotoxic lymphocytes.

Alexandra Flemming
Research Highlight 30 Apr 2020
MDSC metabolite stuns T cells

A new study shows how myeloid-derived suppressor cells paralyse CD8⁺ T cell effector functions by transferring the metabolite methylglyoxal directly into the T cell cytosol, where it depletes essential amino acids.

Lucy Bird
Research Highlight 04 May 2020
SARS-CoV-2-reactive T cells in patients and healthy donors

Luisanna Pia

Collection:

COVID-19 Watch
In Brief 30 Apr 2020
Inactivated vaccine for SARS-CoV-2

Emma Risson

Collection:

COVID-19 Watch
In Brief 30 Apr 2020
Impaired interferon signature in severe COVID-19

Conor Gruber

Collection:

COVID-19 Watch
In Brief 30 Apr 2020
Deborah Doniach, a pioneer in the field of autoimmunity

In this article from our Women in Immunology series, Anne Cooke highlights the pioneering work of Deborah Doniach in the field of autoimmunity.

Anne Cooke
Research Highlight 15 Apr 2020

Top of page ⤴

Progress

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

This Progress article from Merad and Martin examines our current understanding of the excessive inflammatory responses seen in patients with severe COVID-19. The authors focus on the emerging pathological roles of monocytes and macrophages and discuss the inflammatory pathways that are currently being targeted in the clinic.

Miriam Merad
Jerome C. Martin

Collection:

COVID-19 Watch
Progress 06 May 2020

Top of page ⤴

Reviews

The trinity of COVID-19: immunity, inflammation and intervention

In the short time since SARS-CoV-2 infections emerged in humans, much has been learned about the immunological processes that underlie the clinical manifestation of COVID-19. Here, the authors provide an overview of the pathophysiology of SARS-CoV-2 infection and discuss potential therapeutic approaches.

Matthew Zirui Tay
Chek Meng Poh
Lisa F. P. Ng

Collection:

COVID-19 Watch
Review Article 28 Apr 2020
Defining trained immunity and its role in health and disease

Here a group of leaders in the field define our current understanding of ‘trained immunity’, which refers to the memory-type responses that occur in the innate immune system. The authors discuss our current understanding of the key epigenetic and metabolic processes involved in trained immunity and consider its relevance in immune-mediated diseases and cancer.

Mihai G. Netea
Jorge Domínguez-Andrés
Eicke Latz

Collection:

COVID-19 Watch
Review Article 04 Mar 2020

Top of page ⤴

Volume 20 Issue 6, June 2020

Comment

BCG-induced trained immunity: can it offer protection against COVID-19?

Advancing scientific knowledge in times of pandemics

The potential danger of suboptimal antibody responses in COVID-19

Will helminth co-infection modulate COVID-19 severity in endemic regions?

Complement as a target in COVID-19?

COVID-19: a case for inhibiting IL-17?

COVID-19 vaccine design: the Janus face of immune enhancement

Research Highlights

Blocking SIRPα could restore macrophage appetite and mitigate pneumonia

Human antibodies can neutralize SARS-CoV-2

Coronaviruses hijack the complement system

Hydroxychloroquine: small effects in mild disease

Ironing out the details of intestinal repair

HIV hides in platelets

Will we see protection or reinfection in COVID-19?

Macrophages: a Trojan horse in COVID-19?

A map of SARS-CoV-2 and host cell interactions

Does asthma make COVID-19 worse?

Neutralizing antibody response in mild COVID-19

Cancer therapy tool informs COVID-19 vaccines

Tumours use NETs as physical shields

MDSC metabolite stuns T cells

SARS-CoV-2-reactive T cells in patients and healthy donors

Inactivated vaccine for SARS-CoV-2

Impaired interferon signature in severe COVID-19

Deborah Doniach, a pioneer in the field of autoimmunity

Progress

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Reviews

The trinity of COVID-19: immunity, inflammation and intervention

Defining trained immunity and its role in health and disease

Search

Quick links