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Volume 20 Issue 12, December 2020

Volume 20 Issue 12

‘Circadian control’, inspired by the Progress article on p720.

Cover design: Simon Bradbrook.


Research Highlights


  • Progress |

    In this Progress article, Wang and Colonna highlight a flurry of recent reports that have shaped our understanding of how environmental cues and clock genes regulate group 3 innate lymphoid cells. They consider the implications of these findings for intestinal immunity.

    • Qianli Wang
    •  & Marco Colonna


  • Review Article |

    Are you new to virus research and trying to interpret the ever-expanding literature on immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)? Here, the authors compare the different assays and animal models used to measure immunity to SARS-CoV-2 infection and reconcile differences in apparent potency of antibodies assessed in different assays.

    • David S. Khoury
    • , Adam K. Wheatley
    •  & Miles P. Davenport


  • Review Article |

    The ATP–adenosine pathway plays an important role in modulating innate and adaptive immune responses in the tumour microenvironment. Here, the authors focus on CD39, a key enzyme in the ATP–adenosine pathway, and examine immunotherapeutic strategies that target it.

    • Achim K. Moesta
    • , Xian-Yang Li
    •  & Mark J. Smyth
  • Review Article |

    The authors compare the thymic development of several innate-like T cell populations, including natural killer T cells, mucosal-associated invariant T cells and γδ T cells. They focus on the cytokines, surface molecules and transcription factors that are necessary for the development of these cells and highlight some of the key differences from conventional T cell development.

    • Daniel G. Pellicci
    • , Hui-Fern Koay
    •  & Stuart P. Berzins



  • Perspective |

    Why does the human genome encode more than 300 potential immune inhibitory receptors? Here, the authors propose a categorization of inhibitory receptors — as threshold receptors and negative feedback receptors — that reflects their distinct functions in immune regulation, illustrated using mathematical modelling. This categorization may be useful for the therapeutic targeting of inhibitory receptors.

    • Matevž Rumpret
    • , Julia Drylewicz
    •  & Linde Meyaard


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