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Volume 20 Issue 11, November 2020

‘A Guide to Cancer Immunotherapy’, inspired by the Review on p651.

Cover design: Simon Bradbrook.

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Research Highlights

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Reviews

  • T cells play a central role in immune responses to cancer. In this guide to cancer immunotherapy, the authors provide a comprehensive historical and biological perspective on cancer immunotherapy, with a focus on current and emerging therapeutic approaches that harness T cells to fight cancer.

    • Alex D. Waldman
    • Jill M. Fritz
    • Michael J. Lenardo

    Collection:

    Review Article
  • The clinical activity of cyclin-dependent kinase 4 (CDK4)/CDK6 inhibitors has largely been attributed to their capacity to block the proliferation of tumour cells, but increasing evidence discussed in this Review suggests that these inhibitors also have immunomodulatory effects that promote antitumour immune responses.

    • Giulia Petroni
    • Silvia C. Formenti
    • Lorenzo Galluzzi
    Review Article
  • Clonal expansion is no longer only the preserve of adaptive lymphocytes. Innate lymphocytes, in particular natural killer cells, also undergo clonal expansion in response to infection. Here, the authors compare and contrast this process for adaptive and innate lymphocytes.

    • Nicholas M. Adams
    • Simon Grassmann
    • Joseph C. Sun
    Review Article
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Perspectives

  • How does the discovery of SARS-CoV-2 cross-reactive T cells in unexposed individuals change our understanding of the COVID-19 pandemic? In this Perspective, the authors provide a thought experiment to explain why the discovery of cross-reactive T cells may affect disease severity in individuals, but is unlikely to change our estimate of the herd immunity threshold.

    • Marc Lipsitch
    • Yonatan H. Grad
    • Shane Crotty

    Collection:

    Perspective
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