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This study demonstrates that TREM1, an amplifier of inflammation, is induced on peripheral myeloid cells in response to stroke and uncovers an intriguing connection between the brain, the gut and the immune system.
Levels of CCR5 expression by CD4+ T cells, which influence the outcome of HIV-1 infection, are modulated by polymorphism of a non-coding RNA that affects mRNA stability.
A new study shows that neutrophils collaborate with tumour-associated macrophages and unconventional innate-like T cells to mount type 1 antitumour immunity.
Six studies describe a role for TOX in promoting an ‘exhausted’ CD8+ T cell phenotype in settings of chronic antigenic stimulation, such as persistent viral infections and cancer.
The NLRP3 inflammasome mediates pro-inflammatory responses and pyroptotic cell death. Here, the authors describe the complex pathways controlling its activation and regulation and how it is being targeted to treat inflammatory diseases.
Here, Ho and Kupper detail how T cell responses are generated and maintained in skin. They discuss how the various subsets of skin-resident T cells — including memory and innate-like populations — contribute to inflammatory skin disorders.
This Review covers new insights into the immune roles of complement. The authors discuss the pathways that link complement signalling with homeostatic and pathological T cell responses and highlight how complement components act intracellularly to shape T cell responses.
This Review presents evidence that supports a role for the immune system in the pathogenesis of hypertension, including the immune cell subsets involved and the means by which these immune cells become activated throughout the course of the disease.
