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Trifunctional antibodies, binding to the natural killer cell receptors NKp46 and CD16, as well as a tumour antigen, show promising activity in preclinical experiments.
Two new studies identify the discrete stromal cell subtypes that produce IL-33 in adipose tissue to support the immune cells that maintain adipose tissue homeostasis.
The response to anti-PD1 therapy depends on the expression of CXCR3 ligands by dendritic cells in the tumour, which promote the proliferation and activation of intratumoural CD8+ T cells.
Expression of VCAM1 on brain endothelium increases with age and targeting VCAM1 reverses microglial cell activation and cognitive deficits in older mice.
This Review describes the diverse and dynamic chromatin modifications that ensure rapid and appropriate innate immune responses to infection. It also discusses how pathogens themselves modify host responses through epigenetic mechanisms to evade elimination.
This Review considers the link between pain and the immune system. Nociceptors are directly activated by immune mediators and microbial products and, in turn, release neuropeptides that shape immune responses. These neuroimmune pathways can contribute to protective immunity from infections but also lead to chronic pain.
Some immune cells undergo processes that pose unique challenges to the 3D organization of their genomes. These include antigen receptor rearrangement, clonal expansion and the contortion of their nuclei. Here, Allan and colleagues discuss the latest insights into these processes from a structural genomics perspective.
John Harty and colleagues explain how different subsets of CD4+ T cells, CD8+ T cells and γδ T cells respond to the Plasmodium parasites that cause malaria. They discuss the major challenges that need to be overcome in order to harness T cell responses for malaria vaccines and therapies.
