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Chimeric antigen receptor (CAR) T cells directed at fibroblast activation protein show efficacy in mouse models of hypertensive cardiac injury and fibrosis.
Two papers by Gregory Barton and colleagues identify distinct UNC93B1-dependent mechanisms for regulation of the endosomal nucleic acid-sensing TLRs, TLR7 and TLR9.
Prue Hart describes a 1983 paper by De Fabo and Noonan that identified urocanic acid as a major photoreceptor for ultraviolet radiation in the skin that induces systemic immunosuppression.
Commensal bacteria at mucosal surfaces can remotely control the thymic maturation of mucosal-associated invariant T cells through the production of microbial factors that enter the circulation and are taken up by thymic cells.
This study investigates the roles of mutational burden and clonal heterogeneity in immune responses to melanoma and finds that low tumour heterogeneity is a predictor of favourable responses to immunotherapy.
In this Viewpoint article, Nature Reviews Immunology invites 18 experts to discuss the nature of T cell exhaustion. How should T cell exhaustion be defined and what are the developmental relationships between exhausted T cell subsets? The contributors share their thoughts on key recent developments in the field.
The identification of suitable tumour-specific antigens, which can be targeted by vaccine-based or T cell-based immunotherapies, is challenging. This Review explores the potential of alternative splicing to generate unique tumour antigens and discusses methods for their identification.
Ultraviolet radiation (UVR) modulates innate and adaptive immune responses at both local and systemic levels; understanding the mechanisms of this immunomodulatory capacity can explain how UVR has both beneficial and detrimental effects.
Sleep enhances immune defences, and afferent signals from immune cells promote sleep. However, in response to chronic stressors, the normally adaptive function of sleep can become dysregulated, with implications for inflammatory and antiviral responses.
