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Volume 18 Issue 8, August 2018

‘Deciphering TCR signalling’, inspired by the Review on p485

Cover design: Simon Bradbrook

Research Highlights

  • CD4+ TH9 cells show superior activity in adoptive cell transfer approach in melanoma mouse model.

    • Alexandra Flemming
    Research Highlight

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  • The antiviral protein viperin catalyses the production of a small molecule inhibitor of viral RNA polymerization.

    • Kirsty Minton
    Research Highlight
  • Pulmonary neuroendocrine cells communicate with type 2 innate lymphoid cells and goblet cells to promote allergic asthma.

    • Lucy Bird
    Research Highlight
  • Tumour cell-intrinsic factors determine the infiltration of T cells into tumours and their response to immunotherapy.

    • Grant Otto
    Research Highlight
  • The ATP sensor P2RX7 maintains mitochondrial function in long-lived memory CD8+ T cells.

    • Yvonne Bordon
    Research Highlight
  • The metabolism and maintenance of natural killer (NK) cells is regulated by a previously uncharacterized transcription factor called regulatory factor X7 (RFX7).

    • Lucy Bird
    Research Highlight
  • Thirumala-Devi Kanneganti describes a 2002 study by Jürg Tschopp and colleagues that first described the multiprotein, caspase-activating inflammasome complex that drives the maturation and secretion of IL-1β.

    • Thirumala-Devi Kanneganti
    Journal Club
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Reviews

  • This Review discusses the latest insights into the mechanisms regulating T cell receptor (TCR) signalling responses. In particular, the authors focus on how TCR signalling is regulated during thymocyte selection and during T cell homeostasis.

    • Guillaume Gaud
    • Renaud Lesourne
    • Paul E. Love
    Review Article
  • Oncolytic viruses can target multiple steps in the cancer–immunity cycle and can be engineered to express therapeutic genes and, as a result, can be usefully integrated in combination tumour immunotherapies. Here, the authors discuss features of oncolytic viruses that make them appealing agents for combination approaches in cancer immunotherapy.

    • Praveen K. Bommareddy
    • Megha Shettigar
    • Howard L. Kaufman
    Review Article
  • The intestine harbours a complex array of intraepithelial lymphocytes that patrol the epithelial layer and exert rapid cytolytic function. Here, the authors compare the different cytolytic populations and suggest that this diversity results from evolutionary pressure to protect this important barrier.

    • Benjamin D. McDonald
    • Bana Jabri
    • Albert Bendelac
    Review Article
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Perspectives

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Amendments & Corrections

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