Volume 18 Issue 12, December 2018

Eukaryotic translation initiation complex eIF4F is identified as an upstream regulator of PD-L1 expression and is therefore a promising target for immunotherapy.

The gut microbiota and intestinal immune cells profoundly affect each other, an interaction that can be manipulated with antibiotics and probiotics.

A new guide to immunopharmacology seeks to bring the most valuable pharmacological data into the hands of immunology researchers.

CD4⁺ T cell cytokines in the intestinal crypts balance intestinal stem cell renewal and differentiation.

Using spiky microparticles, the authors show that physical cues, such as topological features on the surface of a pathogen, can trigger an immune response by exerting mechanical stress on immune cells.

Two studies describe distinct mechanisms of resistance to anti-CD19 chimeric antigen receptor (CAR) T cell therapy in relapsed leukaemia patients

Recent studies have characterized complex interactions between resident and infiltrating immune cells in the heart and cardiac cells, including cardiomyocytes, fibroblasts and endothelial cells. This Review explores the role of immune cells in cardiac development and physiological function, as well as heart disease.

A-DAM good Review discussing the role of ADAM protein-mediated cleavage of a wide range of substrates in the development and regulation of the immune system, with a focus on ADAM10 and ADAM17.

In this Review, Shi and Holtzman highlight our growing understanding of the innate immune mechanisms that contribute to Alzheimer disease with a specific focus on microglial cells, apolipoprotein E (APOE) and triggering receptor expressed on myeloid cells 2 (TREM2).

This Review considers the key roles of the IL-6 cytokine family in regulating innate and adaptive immunity, as well as other physiological responses. The authors highlight the potential of targeting IL-6 family members to treat inflammatory diseases and cancer.