Volume 10 Issue 2, February 2010
From The Editors
In the News
This Review provides a comprehensive and contemporary overview of the interleukin-1 (IL-1) family: their expression and regulation, their effects on innate immune cells, their regulation of adaptive immune responses and their roles in immune-mediated diseases.
The most recently described member of the interleukin-1 (IL-1) family, IL-33, as described in this Review, has an important role in immune regulation, as well as in infectious and inflammatory diseases, and thereby could have therapeutic potential.
Here, the authors review the fast-moving field of gene expression regulation by microRNAs. They describe how microRNAs influence many stages of innate and adaptive immune responses and how they might precipitate cancer and autoimmune disease if dysregulated.
This Review describes how microbial or self DNA that enters the cytoplasm can be detected by various mechanisms and triggers a range of cellular responses. These include the induction of antiviral innate immune responses and inflammasome-dependent caspase-1 activation and pyroptotic cell death.
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
The intestinal epithelium expresses several Toll-like receptors (TLRs), which are crucial to its effective barrier function and repair following injury. But epithelial cell TLR signalling must be carefully controlled as its dysregulation has been linked to inflammation-associated colorectal cancers.
In this Opinion article, the authors suggest that more extensive use of laboratory measurements could help to expedite clinical trials of immunotherapy. They propose that surrogate end points could be used in place of clinical end points to determine drug safety, disease progression and therapeutic efficacy.