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Volume 10 Issue 10, October 2010

From The Editors

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Research Highlight

  • Tuberculosis disease is associated with an interferon-inducible gene expression signature.

    • Lucy Bird
    Research Highlight
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In Brief

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In the News

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Research Highlight

  • Neutrophil recruitment to joints during arthritis requires a lipid–cytokine–chemokine recruitment cascade.

    • Olive Leavy
    Research Highlight
  • IL-23-activated γδ T cells promote inflammation by suppressing TRegcells.

    • Yvonne Bordon
    Research Highlight
  • DCs promote protective immunity following intracellular detection of HIV-1 capsid protein.

    • Yvonne Bordon
    Research Highlight
  • Bacteria-induced gap junctions allow transfer of tumour antigens to dendritic cells.

    • Lucy Bird
    Research Highlight
  • β-catenin signalling in intestinal DCs promotes mucosal homeostasis.

    • Olive Leavy
    Research Highlight
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In Brief

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Progress

  • Interleukin-9 (IL-9) has recently entered the limelight owing to the discovery that it can be produced by multiple T helper cell subsets. This Progress article updates us on the cellular sources, targets and immune functions of IL-9.

    • Randolph J. Noelle
    • Elizabeth C. Nowak
    Progress
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Review Article

  • Recent research has uncovered new roles for the NOD-like receptors (NLRs) and three types of inflammasome in the inflammatory response to viral infection, the importance of which is highlighted by the viral inhibitors that target these pathways.

    • Thirumala-Devi Kanneganti
    Review Article
  • Immune responses in the genital tract are different to those at other mucosal surfaces. In this Review, Akiko Iwasaki explains how the anatomy of the genital mucosa affects the immune response to viral infection and describes the challenges that are faced in the development of vaccines against sexually transmitted viruses.

    • Akiko Iwasaki
    Review Article
  • The extracellular matrix (ECM) has crucial, though often overlooked, roles during the development of an inflammatory response. Lydia Sorokin describes the interactions that occur between leukocytes and the ECM and discusses how aberrant regulation of ECM components may promote chronic inflammation.

    • Lydia Sorokin
    Review Article
  • This article discusses the current models of how ligation of inhibitory receptors on NK cells by host MHC class I molecules can result in 'educated' NK cells and the recent insights into the signalling pathways that are involved. How MHC class I molecules can regulate receptor repertoire formation in NK cells is also discussed.

    • Petter Höglund
    • Petter Brodin
    Review Article
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Opinion

  • This Perspective article describes the ways in which the intestinal microbiota can interact with the host immune system to promote both pro- and anti-inflammatory immune responses. The authors discuss the important implications of this for not only intestinal, but also for systemic inflammatory diseases.

    • Nadine Cerf-Bensussan
    • Valérie Gaboriau-Routhiau
    Opinion
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